Localisation and regulation of the eIF4E-binding protein 4E-BP3
Localisation and regulation of the eIF4E-binding protein 4E-BP3
The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.
eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus
319-323
Kleijn, M.
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Scheper, G.C.
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Wilson, M.L.
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Tee, A.R.
1b63bc1f-d26b-447f-9429-e83d2468e068
Proud, C.G.
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1 December 2002
Kleijn, M.
ea3c4e21-9929-4b8e-bc40-c8195a8b17ff
Scheper, G.C.
f82821cd-4256-4df9-943b-31760b4aa176
Wilson, M.L.
9a94b485-c57c-4523-a19e-c044c93fd5a1
Tee, A.R.
1b63bc1f-d26b-447f-9429-e83d2468e068
Proud, C.G.
c2cc50f9-4565-4d59-9dfc-aa70b9268a6e
Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R. and Proud, C.G.
(2002)
Localisation and regulation of the eIF4E-binding protein 4E-BP3.
FEBS Letters, 532 (3), .
Abstract
The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.
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Submitted date: 25 August 2002
Published date: 1 December 2002
Keywords:
eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus
Identifiers
Local EPrints ID: 56620
URI: http://eprints.soton.ac.uk/id/eprint/56620
ISSN: 0014-5793
PURE UUID: cb58af72-9f67-439b-a779-6421a86d4aff
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Date deposited: 07 Aug 2008
Last modified: 07 Jan 2022 22:32
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Contributors
Author:
M. Kleijn
Author:
G.C. Scheper
Author:
M.L. Wilson
Author:
A.R. Tee
Author:
C.G. Proud
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