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Localisation and regulation of the eIF4E-binding protein 4E-BP3

Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R. and Proud, C.G. (2002) Localisation and regulation of the eIF4E-binding protein 4E-BP3 Febs Letters, 532, (3), pp. 319-323.

Record type: Article


The cap-binding protein eIF4E-binding protein 3 (4E-BP3) was identified some years ago, but its properties have not been investigated in detail. In this report, we investigated the regulation and localisation of 4E-BP3. We show that 4E-BP3 is present in the nucleus as well as in the cytoplasm in primary T cells, HEK293 cells and HeLa cells. 4E-BP3 was associated with eIF4E in both cell compartments. Furthermore, 4E-BP3/eIF4E association in the cytoplasm was regulated by serum or interleukin-2 starvation in the different cell types. Rapamycin did not affect the association of eIF4E with 4E-BP3 in the cytoplasm or in the nucleus.

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Submitted date: 25 August 2002
Published date: 1 December 2002
Keywords: eIF4E-binding protein 3, eIF4E-binding protein 1, primary T cell, regulation, nucleus


Local EPrints ID: 56620
ISSN: 0014-5793
PURE UUID: cb58af72-9f67-439b-a779-6421a86d4aff

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Author: M. Kleijn
Author: G.C. Scheper
Author: M.L. Wilson
Author: A.R. Tee
Author: C.G. Proud

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