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Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans

Dillon, J., Hopper, N.A., Holden-Dye, L. and Connor, V. (2006) Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans Biochemical Society Transactions, 34, (5), pp. 942-948.

Record type: Article

Abstract

mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of three distinct subclasses of receptor. Our transcript analysis highlights potential for complex gene regulation with respect to both expression and splicing. Further, we identify that the predicted proteins encoded by mgls harbour structural motifs that are likely to regulate function. Taken together, this molecular characterization provides a platform to further investigate mGluR function in the model organism C. elegans.

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More information

Published date: 1 November 2006
Keywords: Caenorhabditis elegans, G-protein-coupled receptor, metabotropic glutamate receptor, molecular characterization, rapid amplification of cDNA ends (RACE), splice leader-1 (SL-1)

Identifiers

Local EPrints ID: 56651
URI: http://eprints.soton.ac.uk/id/eprint/56651
ISSN: 0300-5127
PURE UUID: ed0ea204-dc78-43f3-8dca-8603f2cb59ab

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: J. Dillon
Author: N.A. Hopper
Author: L. Holden-Dye
Author: V. Connor

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