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Green or red: what stops the traffic in the tetrapyrrole pathway?

Green or red: what stops the traffic in the tetrapyrrole pathway?
Green or red: what stops the traffic in the tetrapyrrole pathway?
Regulation of tetrapyrrole biosynthesis is crucial to plant metabolism. The two pivotal control points are formation of the initial precursor, 5-aminolaevulinic acid (ALA), and the metal-ion insertion step: chelation of Fe2+ into protoporphyrin IX leads to haem and phytochromobilin, whereas insertion of Mg2+ is the first step to chlorophyll. Recent studies with mutants and transgenic plants have demonstrated that perturbation of the branch point affects ALA formation. Moreover, one of the signals that controls the expression of genes for nuclear-encoded chloroplast proteins has been shown to be Mg–protoporphyrin-IX. Here, we discuss the regulation of branch-point flux and the relative contributions of the haem and chlorophyll branches to the regulation of ALA synthesis and thus to flow through the tetrapyrrole pathway.
1360-1385
224-230
Cornah, Johanna E.
ca61f87f-5f15-46de-b11a-544ef1c723d0
Terry, Matthew J.
a8c2cd6b-8d35-4053-8d77-3841c2427c3b
Smith, Alison G.
30d591f0-8608-47bf-89ee-9278c4bef53d
Cornah, Johanna E.
ca61f87f-5f15-46de-b11a-544ef1c723d0
Terry, Matthew J.
a8c2cd6b-8d35-4053-8d77-3841c2427c3b
Smith, Alison G.
30d591f0-8608-47bf-89ee-9278c4bef53d

Cornah, Johanna E., Terry, Matthew J. and Smith, Alison G. (2003) Green or red: what stops the traffic in the tetrapyrrole pathway? Trends in Plant Science, 8 (5), 224-230. (doi:10.1016/S1360-1385(03)00064-5).

Record type: Article

Abstract

Regulation of tetrapyrrole biosynthesis is crucial to plant metabolism. The two pivotal control points are formation of the initial precursor, 5-aminolaevulinic acid (ALA), and the metal-ion insertion step: chelation of Fe2+ into protoporphyrin IX leads to haem and phytochromobilin, whereas insertion of Mg2+ is the first step to chlorophyll. Recent studies with mutants and transgenic plants have demonstrated that perturbation of the branch point affects ALA formation. Moreover, one of the signals that controls the expression of genes for nuclear-encoded chloroplast proteins has been shown to be Mg–protoporphyrin-IX. Here, we discuss the regulation of branch-point flux and the relative contributions of the haem and chlorophyll branches to the regulation of ALA synthesis and thus to flow through the tetrapyrrole pathway.

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Published date: 1 May 2003

Identifiers

Local EPrints ID: 56659
URI: https://eprints.soton.ac.uk/id/eprint/56659
ISSN: 1360-1385
PURE UUID: 11234425-8296-40d4-8060-9267cede1fd0
ORCID for Matthew J. Terry: ORCID iD orcid.org/0000-0001-5002-2708

Catalogue record

Date deposited: 08 Aug 2008
Last modified: 20 Jul 2019 01:17

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