Emodepside, a cyclo-octadepsipeptide anthelmintic with a novel mode of action


Amliwala, K., Bull, K., Willson, J., Harder, A., Holden-Dye, L. and Walker, R.J. (2004) Emodepside, a cyclo-octadepsipeptide anthelmintic with a novel mode of action Drugs of the Future, 29, (10), pp. 1015-1024. (doi:10.1358/dof.2004.029.10.863392).

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Description/Abstract

Due to the development of drug resistance, there is a continual need for new anthelmintics with novel modes of action. Emodepside, a cyclo-octadepsipeptide, was originally thought to modify GABAergic transmission in parasitic nematodes. However, more recent studies using the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans indicate that emodepside interacts with a presynaptic latrophilin receptor to release a transmitter or modulator. This presynaptic signaling pathway involves activation of a Gaq protein and phospholipase-?, which mobilizes diacylglycerol (DAG). DAG activates UNC-13, which in turn activates synaptobrevin to increase release of the transmitter or modulator. The released transmitter or modulator acts postsynaptically to modify pharyngeal and somatic body wall muscle activity.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1358/dof.2004.029.10.863392
ISSNs: 0377-8282 (print)
Subjects:
ePrint ID: 56661
Date :
Date Event
1 October 2004Published
Date Deposited: 08 Aug 2008
Last Modified: 16 Apr 2017 17:41
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/56661

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