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Emodepside, a cyclo-octadepsipeptide anthelmintic with a novel mode of action

Amliwala, K., Bull, K., Willson, J., Harder, A., Holden-Dye, L. and Walker, R.J. (2004) Emodepside, a cyclo-octadepsipeptide anthelmintic with a novel mode of action Drugs of the Future, 29, (10), pp. 1015-1024. (doi:10.1358/dof.2004.029.10.863392).

Record type: Article

Abstract

Due to the development of drug resistance, there is a continual need for new anthelmintics with novel modes of action. Emodepside, a cyclo-octadepsipeptide, was originally thought to modify GABAergic transmission in parasitic nematodes. However, more recent studies using the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans indicate that emodepside interacts with a presynaptic latrophilin receptor to release a transmitter or modulator. This presynaptic signaling pathway involves activation of a Gaq protein and phospholipase-?, which mobilizes diacylglycerol (DAG). DAG activates UNC-13, which in turn activates synaptobrevin to increase release of the transmitter or modulator. The released transmitter or modulator acts postsynaptically to modify pharyngeal and somatic body wall muscle activity.

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Published date: 1 October 2004

Identifiers

Local EPrints ID: 56661
URI: http://eprints.soton.ac.uk/id/eprint/56661
ISSN: 0377-8282
PURE UUID: fac69b71-5616-4abb-a794-068164f8ed47

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Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: K. Amliwala
Author: K. Bull
Author: J. Willson
Author: A. Harder
Author: L. Holden-Dye
Author: R.J. Walker

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