Amliwala, K., Bull, K., Willson, J., Harder, A., Holden-Dye, L. and Walker, R.J.
Emodepside, a cyclo-octadepsipeptide anthelmintic with a novel mode of action
Drugs of the Future, 29, (10), . (doi:10.1358/dof.2004.029.10.863392).
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Due to the development of drug resistance, there is a continual need for new anthelmintics with novel modes of action. Emodepside, a cyclo-octadepsipeptide, was originally thought to modify GABAergic transmission in parasitic nematodes. However, more recent studies using the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans indicate that emodepside interacts with a presynaptic latrophilin receptor to release a transmitter or modulator. This presynaptic signaling pathway involves activation of a Gaq protein and phospholipase-?, which mobilizes diacylglycerol (DAG). DAG activates UNC-13, which in turn activates synaptobrevin to increase release of the transmitter or modulator. The released transmitter or modulator acts postsynaptically to modify pharyngeal and somatic body wall muscle activity.
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