Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

Beugnet, A., Tee, A.R., Taylor, P.M. and Proud, C.G. (2003) Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochemical Journal, 373 (3), p.999.

Record type: Article

Abstract

Volume 372 (2003), pp. 555–566
Here follows a note from the authors of the above paper:
It has been brought to our attention that 3-methyladenine has previously been shown by Meijer and colleagues [1,2] to inhibit members of the phosphatidylinositol 3-kinase family of enzymes. This probably explains why we observed that this compound inhibits the phosphorylation of protein kinase B induced by insulin (Figure 6D of our study). Caution must, as we have pointed out, be exercised when interpreting effects of this compound in intact cells as it is not, as initially thought, a specific reagent for inhibiting autophagy.

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