The University of Southampton
University of Southampton Institutional Repository

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability
Volume 372 (2003), pp. 555–566
Here follows a note from the authors of the above paper:
It has been brought to our attention that 3-methyladenine has previously been shown by Meijer and colleagues [1,2] to inhibit members of the phosphatidylinositol 3-kinase family of enzymes. This probably explains why we observed that this compound inhibits the phosphorylation of protein kinase B induced by insulin (Figure 6D of our study). Caution must, as we have pointed out, be exercised when interpreting effects of this compound in intact cells as it is not, as initially thought, a specific reagent for inhibiting autophagy.
1470-8728
p.999
Beugnet, A.
27018312-ccab-4990-8ae2-f71a85559fec
Tee, A.R.
1b63bc1f-d26b-447f-9429-e83d2468e068
Taylor, P.M.
329d2e7a-e045-4ee6-9a73-6c423b5c0420
Proud, C.G.
c2cc50f9-4565-4d59-9dfc-aa70b9268a6e
Beugnet, A.
27018312-ccab-4990-8ae2-f71a85559fec
Tee, A.R.
1b63bc1f-d26b-447f-9429-e83d2468e068
Taylor, P.M.
329d2e7a-e045-4ee6-9a73-6c423b5c0420
Proud, C.G.
c2cc50f9-4565-4d59-9dfc-aa70b9268a6e

Beugnet, A., Tee, A.R., Taylor, P.M. and Proud, C.G. (2003) Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochemical Journal, 373 (3), p.999.

Record type: Article

Abstract

Volume 372 (2003), pp. 555–566
Here follows a note from the authors of the above paper:
It has been brought to our attention that 3-methyladenine has previously been shown by Meijer and colleagues [1,2] to inhibit members of the phosphatidylinositol 3-kinase family of enzymes. This probably explains why we observed that this compound inhibits the phosphorylation of protein kinase B induced by insulin (Figure 6D of our study). Caution must, as we have pointed out, be exercised when interpreting effects of this compound in intact cells as it is not, as initially thought, a specific reagent for inhibiting autophagy.

This record has no associated files available for download.

More information

Published date: 1 August 2003

Identifiers

Local EPrints ID: 56689
URI: http://eprints.soton.ac.uk/id/eprint/56689
ISSN: 1470-8728
PURE UUID: 1f1e5c3f-3bde-4b4c-80f0-51baa023aa81

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 08 Jan 2022 01:12

Export record

Contributors

Author: A. Beugnet
Author: A.R. Tee
Author: P.M. Taylor
Author: C.G. Proud

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×