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Increased expression of glial fibrillary acidic protein fragments and mu-calpain activation within the hippocampus of prion-infected mice

Record type: Article

Prion diseases are characteristically accompanied by marked astrocytic activation, which is initiated relatively early in the disease process. Using the intracerebrally injected ME7 strain of prion agent to model disease, we identified an expected increase in GFAP (glial fibrillary acidic protein) but additionally noted an accumulation of GFAP cleavage fragments in hippocampal homogenates. A time-dependent increase in hippocampal m-calpain immunoreactivity within astrocytes suggests that its proteolytic activity may account for the cleavage of GFAP that is observed in the ME7 model. It may therefore contribute to the reactive gliosis that is characteristic of prion diseases.

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Citation

Gray, B.C., Skipp, P., Connor, V.M. and Perry, V.H. (2006) Increased expression of glial fibrillary acidic protein fragments and mu-calpain activation within the hippocampus of prion-infected mice Biochemical Society Transactions, 34, (1), pp. 51-54.

More information

Published date: 1 February 2006
Keywords: m-calpain, central nervous system, glial fibrillary acidic protein, gliosis, ME7, prion disease

Identifiers

Local EPrints ID: 56708
URI: http://eprints.soton.ac.uk/id/eprint/56708
ISSN: 0300-5127
PURE UUID: cf7b6262-bf0a-40e3-9ab4-a2de2913fc8e
ORCID for P. Skipp: ORCID iD orcid.org/0000-0002-2995-2959

Catalogue record

Date deposited: 06 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: B.C. Gray
Author: P. Skipp ORCID iD
Author: V.M. Connor
Author: V.H. Perry

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