The University of Southampton
University of Southampton Institutional Repository

Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila

Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila

We have used a GAL4 enhancer-trap line driving the expression of a lacZ construct to examine the reorganisation of an identified group of proprioceptive sensory neurons during metamorphosis in Drosophila. The results show that whilst most larval sensory neurons degenerate during the first 24 hours of metamorphosis a segmentally repeated array of 6 neurons per segment persists into the adult stages to become functional adult neurons. These sensory neurons retain their axonal projections in the central nervous system intact and unchanged throughout. The adult sensory neuron axons enter the central nervous system at around 44 hours after puparium formation. Most of these axons grow along the pathways defined by the persistent larval sensory axons. The ordering of the adult sensory projections is, therefore, established upon the larval pattern of projections. The possibility that the larval neurons act as guidance cues for organising the ordered arrays of sensory neurons is discussed.

Animals, Axons/physiology, Central Nervous System/embryology, Drosophila/embryology, Ganglia, Invertebrate/cytology, Lac Operon, Larva, Metamorphosis, Biological, Neural Pathways/cytology, Neurons, Afferent/cytology
1477-9129
2375-2384
Shepherd, D
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Smith, S A
a1bba70b-96a9-46a6-b044-a2a7a0c99223
Shepherd, D
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Smith, S A
a1bba70b-96a9-46a6-b044-a2a7a0c99223

Shepherd, D and Smith, S A (1996) Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila. Development, 122 (8), 2375-2384. (doi:10.1242/dev.122.8.2375).

Record type: Article

Abstract

We have used a GAL4 enhancer-trap line driving the expression of a lacZ construct to examine the reorganisation of an identified group of proprioceptive sensory neurons during metamorphosis in Drosophila. The results show that whilst most larval sensory neurons degenerate during the first 24 hours of metamorphosis a segmentally repeated array of 6 neurons per segment persists into the adult stages to become functional adult neurons. These sensory neurons retain their axonal projections in the central nervous system intact and unchanged throughout. The adult sensory neuron axons enter the central nervous system at around 44 hours after puparium formation. Most of these axons grow along the pathways defined by the persistent larval sensory axons. The ordering of the adult sensory projections is, therefore, established upon the larval pattern of projections. The possibility that the larval neurons act as guidance cues for organising the ordered arrays of sensory neurons is discussed.

This record has no associated files available for download.

More information

Published date: 1 August 1996
Keywords: Animals, Axons/physiology, Central Nervous System/embryology, Drosophila/embryology, Ganglia, Invertebrate/cytology, Lac Operon, Larva, Metamorphosis, Biological, Neural Pathways/cytology, Neurons, Afferent/cytology

Identifiers

Local EPrints ID: 56717
URI: http://eprints.soton.ac.uk/id/eprint/56717
ISSN: 1477-9129
PURE UUID: 1b030aa3-a50c-4946-9d36-a8cc0b003a17
ORCID for D Shepherd: ORCID iD orcid.org/0000-0002-6961-7880

Catalogue record

Date deposited: 22 Aug 2008
Last modified: 06 Aug 2024 01:52

Export record

Altmetrics

Contributors

Author: D Shepherd ORCID iD
Author: S A Smith

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×