Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
We have used a GAL4 enhancer-trap line driving the expression of a lacZ construct to examine the reorganisation of an identified group of proprioceptive sensory neurons during metamorphosis in Drosophila. The results show that whilst most larval sensory neurons degenerate during the first 24 hours of metamorphosis a segmentally repeated array of 6 neurons per segment persists into the adult stages to become functional adult neurons. These sensory neurons retain their axonal projections in the central nervous system intact and unchanged throughout. The adult sensory neuron axons enter the central nervous system at around 44 hours after puparium formation. Most of these axons grow along the pathways defined by the persistent larval sensory axons. The ordering of the adult sensory projections is, therefore, established upon the larval pattern of projections. The possibility that the larval neurons act as guidance cues for organising the ordered arrays of sensory neurons is discussed.
Animals, Axons/physiology, Central Nervous System/embryology, Drosophila/embryology, Ganglia, Invertebrate/cytology, Lac Operon, Larva, Metamorphosis, Biological, Neural Pathways/cytology, Neurons, Afferent/cytology
2375-2384
Shepherd, D
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Smith, S A
a1bba70b-96a9-46a6-b044-a2a7a0c99223
1 August 1996
Shepherd, D
11aa6858-d19c-4450-82ff-11dff9dcd9c4
Smith, S A
a1bba70b-96a9-46a6-b044-a2a7a0c99223
Shepherd, D and Smith, S A
(1996)
Central projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila.
Development, 122 (8), .
(doi:10.1242/dev.122.8.2375).
Abstract
We have used a GAL4 enhancer-trap line driving the expression of a lacZ construct to examine the reorganisation of an identified group of proprioceptive sensory neurons during metamorphosis in Drosophila. The results show that whilst most larval sensory neurons degenerate during the first 24 hours of metamorphosis a segmentally repeated array of 6 neurons per segment persists into the adult stages to become functional adult neurons. These sensory neurons retain their axonal projections in the central nervous system intact and unchanged throughout. The adult sensory neuron axons enter the central nervous system at around 44 hours after puparium formation. Most of these axons grow along the pathways defined by the persistent larval sensory axons. The ordering of the adult sensory projections is, therefore, established upon the larval pattern of projections. The possibility that the larval neurons act as guidance cues for organising the ordered arrays of sensory neurons is discussed.
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Published date: 1 August 1996
Keywords:
Animals, Axons/physiology, Central Nervous System/embryology, Drosophila/embryology, Ganglia, Invertebrate/cytology, Lac Operon, Larva, Metamorphosis, Biological, Neural Pathways/cytology, Neurons, Afferent/cytology
Identifiers
Local EPrints ID: 56717
URI: http://eprints.soton.ac.uk/id/eprint/56717
ISSN: 1477-9129
PURE UUID: 1b030aa3-a50c-4946-9d36-a8cc0b003a17
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Date deposited: 22 Aug 2008
Last modified: 06 Aug 2024 01:52
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Author:
S A Smith
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