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Hippocampal scrapie infection impairs operant DRL performance in mice

Hippocampal scrapie infection impairs operant DRL performance in mice
Hippocampal scrapie infection impairs operant DRL performance in mice
In differential reinforcement of low rates of responding (DRL) tasks, animals are trained to respond for rewards that become available only after some set time has elapsed since the animal's previous response. DRL performance is impaired by hippocampal lesions regardless of their precise location, and can be measured using automated operant equipment, whereas spatial tasks are selectively impaired by dorsal, but not ventral hippocampal lesions, and are typically conducted by hand. Earlier studies of prion infection following dorsal hippocampal microinjections of scrapie have shown clear impairments of spatial alternation, but these occurred significantly later than dysfunction in hippocampus-dependent domestic tasks such as nesting or burrowing. In the present experiment, mice were trained to respond on an automated DRL schedule prior to dorsal hippocampal ME7 scrapie injection. Postoperative DRL performance was monitored, along with performance on domestic and other tests, which provided additional measures of disease progression. Animals with scrapie developed a clear DRL deficit at approximately the same time as their deficits on the other tests became apparent, and long before clinical signs were detectable. DRL deficits thus appeared earlier in the sequence of disease progression than previously reported for spatial alternation, suggesting that early signs of scrapie infection are caused in part by neuronal dysfunction extending beyond the dorsal hippocampal region of initial infection.
0166-4328
99-105
Deacon, R.M.J.
db1b08cb-3bd1-41b4-b665-c8435b753019
Reisel, D.
1c9e063e-90c5-4bfc-9546-673c3ce0aaf1
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Nicholas, J.
aed57b9f-7c12-41db-ae46-4e16e66aacfb
Rawlins, P.
9604859a-cbad-484d-a63e-f7c081263981
Deacon, R.M.J.
db1b08cb-3bd1-41b4-b665-c8435b753019
Reisel, D.
1c9e063e-90c5-4bfc-9546-673c3ce0aaf1
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Nicholas, J.
aed57b9f-7c12-41db-ae46-4e16e66aacfb
Rawlins, P.
9604859a-cbad-484d-a63e-f7c081263981

Deacon, R.M.J., Reisel, D., Perry, V.H., Nicholas, J. and Rawlins, P. (2005) Hippocampal scrapie infection impairs operant DRL performance in mice. Behavioural Brain Research, 157 (1), 99-105.

Record type: Article

Abstract

In differential reinforcement of low rates of responding (DRL) tasks, animals are trained to respond for rewards that become available only after some set time has elapsed since the animal's previous response. DRL performance is impaired by hippocampal lesions regardless of their precise location, and can be measured using automated operant equipment, whereas spatial tasks are selectively impaired by dorsal, but not ventral hippocampal lesions, and are typically conducted by hand. Earlier studies of prion infection following dorsal hippocampal microinjections of scrapie have shown clear impairments of spatial alternation, but these occurred significantly later than dysfunction in hippocampus-dependent domestic tasks such as nesting or burrowing. In the present experiment, mice were trained to respond on an automated DRL schedule prior to dorsal hippocampal ME7 scrapie injection. Postoperative DRL performance was monitored, along with performance on domestic and other tests, which provided additional measures of disease progression. Animals with scrapie developed a clear DRL deficit at approximately the same time as their deficits on the other tests became apparent, and long before clinical signs were detectable. DRL deficits thus appeared earlier in the sequence of disease progression than previously reported for spatial alternation, suggesting that early signs of scrapie infection are caused in part by neuronal dysfunction extending beyond the dorsal hippocampal region of initial infection.

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Published date: 1 February 2005

Identifiers

Local EPrints ID: 56723
URI: https://eprints.soton.ac.uk/id/eprint/56723
ISSN: 0166-4328
PURE UUID: 26eac92c-ff8e-435c-96e3-01d00ca8e495

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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