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Synaptic modulation of the pharyngeal muscle of C. elegans

Holden-Dye, Lindy and Walker, Robert J. (2002) Synaptic modulation of the pharyngeal muscle of C. elegans The Journal of Physiology, 543P, (S324), p.4S.

Record type: Article


The nematode C. elegans feeds by rhythmic contraction of the pharyngeal muscle. The activity of the muscle is modified by environmental cues, e.g. the presence of E. coli increases the rate of pharyngeal activity. The neural circuit that mediates these effects has been completely mapped. However, the role of neurotransmitters in this pathway is not so clear. To address this we have made intracellular recordings from the pharyngeal muscle and characterised its resting properties (Franks et al. 2002). We have determined the response of the pharynx to putative neurotransmitters and neuromodulators (Rogers et al. 2001). By judicious use of mutant strains (Pemberton et al. 2001), or gene interference, physiologically important signalling pathways may be delineated.

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Published date: 1 October 2002
Organisations: Biological Sciences


Local EPrints ID: 56731
ISSN: 0022-3751
PURE UUID: 5081121a-dc56-4df8-a44a-fcfb6d5c1aa8

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Date deposited: 11 Aug 2008
Last modified: 17 Jul 2017 14:30

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Author: Robert J. Walker

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