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Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis

Sale, Elizabeth M., Atkinson, Peter P.G., Arnott, Caroline H., Chad, John E. and Sale, Graham J. (1999) Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis Febs Letters, 446, (1), pp. 122-126. (doi:10.1016/S0014-5793(99)00193-3).

Record type: Article


The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.

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Published date: 5 March 1999
Keywords: insulin, protein synthesis, extracellular signal regulated kinase 1, extracellular signal regulated kinase 2, p70(S6k), antisense


Local EPrints ID: 56751
ISSN: 0014-5793
PURE UUID: c20701d0-2c98-4ab1-b131-0346fd47123e
ORCID for John E. Chad: ORCID iD

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Date deposited: 22 Aug 2008
Last modified: 17 Jul 2017 14:30

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Author: Elizabeth M. Sale
Author: Peter P.G. Atkinson
Author: Caroline H. Arnott
Author: John E. Chad ORCID iD
Author: Graham J. Sale

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