Sale, Elizabeth M., Atkinson, Peter P.G., Arnott, Caroline H., Chad, John E. and Sale, Graham J.
Role of ERK1/ERK2 and p70(S6K) pathway in insulin signalling of protein synthesis
Febs Letters, 446, (1), . (doi:10.1016/S0014-5793(99)00193-3).
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The signalling pathways by which insulin triggers protein synthesis were studied using an antisense strategy to deplete ERK1/ERK2 and rapamycin to inhibit the p70(S6K) pathway. The results indicated that ERK1/ERK2 principally regulated the amount of the protein synthesis machinery available in the cell while the p70S6K pathway contributed to modulating its activation in response to insulin. ERK1/ERK2 also mediated in a small proportion of insulin-stimulated protein synthesis which included the induction of c-fos protein. When c-fos induction was blocked the majority of insulin-stimulated protein synthesis still occurred and thus did not require transcriptional regulation of c-fos or its targets.
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