The University of Southampton
University of Southampton Institutional Repository

Analysis of skin of nidogen deficient mouse models

Record type: Article

Basement membranes (BMs) are produced by complex interactions of laminins, collagen IV, perlecan and nidogen. Nidogen represents a small family of related proteins with two mammalian isoforms nidogen 1 and 2. Nidogens are ubiquitous BM components that have been proposed to play a key role for BM assembly. However, neither nidogen 1 nor nidogen 2 deficient mice showed BM defects suggesting overlapping functions of the two isoforms for the formation of BMs. Nidogen double null mice showed that this is indeed 1the case. These mice die shortly after birth showing various abnormalities particularly in the lung, heart and limb, directly related to BM defects. However, despite the fact that both nidogens are found in all BMs, some BMs in these mice appeared ultrastructurally normal. Mice lacking the high affinity binding site on the laminin g1 chain that is present in most laminin isoforms showed strikingly different phenotypes. While changes in the lung are common, these mice do not display cardiac changes and show a highly penetrant renal aplasia not seen in nidogen double null mice. We were therefore interested to analyse the skin phenotype in these mice in comparison to the nidogen double null mice to understand the biological contribution of the laminin nidogen interactions for nidogen function in skin development. Detailed analysis of the skin BMs revealed different phenotypes between the two mouse strains indicating differences in the role of nidogens and the laminin nidogen interaction for skin physiology.

Full text not available from this repository.

Citation

Mokkapati, S., Baranowsky, A., Reibetanz, M., Smyth, N. and Nischt, R. (2006) Analysis of skin of nidogen deficient mouse models Matrix Biology, 25, (1), S82-S82. (doi:10.1016/j.matbio.2006.08.225).

More information

Published date: November 2006

Identifiers

Local EPrints ID: 56758
URI: http://eprints.soton.ac.uk/id/eprint/56758
ISSN: 0945-053X
PURE UUID: ec6671f5-8464-4cb7-8576-43f3f016898c

Catalogue record

Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:30

Export record

Altmetrics

Contributors

Author: S. Mokkapati
Author: A. Baranowsky
Author: M. Reibetanz
Author: N. Smyth
Author: R. Nischt

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×