Ephrin tempers two-faced synaptojanin 1
Ephrin tempers two-faced synaptojanin 1
Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.
454-456
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
O'Connor, Vincent
b005270b-0ec5-4429-874e-2f08c43cf86d
May 2005
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
O'Connor, Vincent
b005270b-0ec5-4429-874e-2f08c43cf86d
Hopper, Neil A. and O'Connor, Vincent
(2005)
Ephrin tempers two-faced synaptojanin 1.
Nature Cell Biology, 7 (5), .
(doi:10.1038/ncb0505-454).
Abstract
Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.
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Published date: May 2005
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Local EPrints ID: 56767
URI: http://eprints.soton.ac.uk/id/eprint/56767
ISSN: 1465-7392
PURE UUID: 0a0806b9-8404-4325-999e-0892c65e148e
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Date deposited: 08 Aug 2008
Last modified: 15 Mar 2024 11:03
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Author:
Neil A. Hopper
Author:
Vincent O'Connor
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