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Ephrin tempers two-faced synaptojanin 1

Ephrin tempers two-faced synaptojanin 1
Ephrin tempers two-faced synaptojanin 1
Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.
1465-7392
454-456
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
O'Connor, Vincent
b005270b-0ec5-4429-874e-2f08c43cf86d
Hopper, Neil A.
d2aed184-733b-47f6-8d74-fa1633ae6cf0
O'Connor, Vincent
b005270b-0ec5-4429-874e-2f08c43cf86d

Hopper, Neil A. and O'Connor, Vincent (2005) Ephrin tempers two-faced synaptojanin 1. Nature Cell Biology, 7 (5), 454-456. (doi:10.1038/ncb0505-454).

Record type: Article

Abstract

Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.

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More information

Published date: May 2005

Identifiers

Local EPrints ID: 56767
URI: https://eprints.soton.ac.uk/id/eprint/56767
ISSN: 1465-7392
PURE UUID: 0a0806b9-8404-4325-999e-0892c65e148e

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Date deposited: 08 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: Neil A. Hopper
Author: Vincent O'Connor

University divisions

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