The University of Southampton
University of Southampton Institutional Repository

An antigen-specific pathway for CD8 T cells across the blood-brain barrier

Galea, Ian, Bernardes-Silva, Martine, Forse, Penny A., van Rooijen, Nico, Liblau, Roland S. and Perry, V. Hugh (2007) An antigen-specific pathway for CD8 T cells across the blood-brain barrier The Journal of Experimental Medicine, 204, (9), pp. 2023-2030. (doi:10.1084/jem.20070064).

Record type: Article

Abstract

CD8 T cells are nature's foremost defense in encephalitis and brain tumors. Antigen-specific CD8 T cells need to enter the brain to exert their beneficial effects. On the other hand, traffic of CD8 T cells specific for neural antigen may trigger autoimmune diseases like multiple sclerosis. T cell traffic into the central nervous system is thought to occur when activated T cells cross the blood-brain barrier (BBB) regardless of their antigen specificity, but studies have focused on CD4 T cells. Here, we show that selective traffic of antigen-specific CD8 T cells into the brain occurs in vivo and is dependent on luminal expression of major histocompatibility complex (MHC) class I by cerebral endothelium. After intracerebral antigen injection, using a minimally invasive technique, transgenic CD8 T cells only infiltrated the brain when and where their cognate antigen was present. This was independent of antigen presentation by perivascular macrophages. Marked reduction of antigen-specific CD8 T cell infiltration was observed after intravenous injection of blocking anti–MHC class I antibody. These results expose a hitherto unappreciated route by which CD8 T cells home onto their cognate antigen behind the BBB: luminal MHC class I antigen presentation by cerebral endothelium to circulating CD8 T cells. This has implications for a variety of diseases in which antigen-specific CD8 T cell traffic into the brain is a beneficial or deleterious feature.

PDF __soton.ac.uk_ude_personalfiles_users_ig1_mydesktop_Staff profile_Galea et al 2007 JEM.pdf - Version of Record
Download (4MB)

More information

Submitted date: 5 January 2007
Published date: 3 September 2007

Identifiers

Local EPrints ID: 56802
URI: http://eprints.soton.ac.uk/id/eprint/56802
ISSN: 0022-1007
PURE UUID: ddf1794d-b9b4-4782-a243-9d01369578b7
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

Catalogue record

Date deposited: 11 Aug 2008
Last modified: 17 Jul 2017 14:30

Export record

Altmetrics

Contributors

Author: Ian Galea ORCID iD
Author: Martine Bernardes-Silva
Author: Penny A. Forse
Author: Nico van Rooijen
Author: Roland S. Liblau
Author: V. Hugh Perry

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×