The multifaceted role of mTOR in cellular stress responses

Proud, C.G. (2004) The multifaceted role of mTOR in cellular stress responses DNA Repair, 3, (8-9), pp. 927-934. (doi:10.1016/j.dnarep.2004.03.012).


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The mammalian target of rapamycin (mTOR) is a large multidomain protein whose function is inhibited by the immunosuppressant drug rapamycin. mTOR (or its homologues in lower eukaryotes) plays roles in cell growth and the cell cycle, control of the cytoskeleton and nutrient transport, protein and RNA stability and transcription and translation. In mammalian cells, the best understood effectors of mTOR are proteins involved in controlling the translational machinery. Signalling through mTOR is stimulated by amino acids and by hormones and mitogens. On the other hand, mTOR signaling is impaired in response to a range of stressful stimuli. These include DNA damage, nutrient withdrawal and depletion of cellular energy, as well as hypoxia. In response, e.g. to DNA damage, impairment of mTOR signaling appears to precede the commitment of cells to apoptosis. The mechanisms by which these stressful conditions still remain largely unclear. However, these responses make physiological sense, as impairment of mTOR signalling under these conditions will tend to inhibit anabolic processes and cell growth and division.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.dnarep.2004.03.012
ISSNs: 1568-7864 (print)
Keywords: mTOR, signaling, amino acids, DNA damage, apoptosis, hypoxia
ePrint ID: 56803
Date :
Date Event
1 August 2004Published
Date Deposited: 08 Aug 2008
Last Modified: 16 Apr 2017 17:40
Further Information:Google Scholar

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