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Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes

Wang, Lijun and Proud, Christopher G. (2002) Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes Febs Letters, 531, (2), pp. 285-289. (doi:10.1016/S0014-5793(02)03536-6).

Record type: Article

Abstract

The Gq-coupled agonists phenylephrine and endothelin-1 each activate protein synthesis in cardiomyocytes as part of the programme that leads to cardiac hypertrophy. Here we show that they each induce the dephosphorylation of elongation factor (eEF) 2, a protein that in its dephosphorylated state mediates the translocation step of elongation. The ability of both agonists to induce dephosphorylation of eEF2 requires signalling via the mTOR and MEK/Erk signalling pathways, but is independent of phosphoinositide 3-kinase. Expression of an activated form of MEK leads to dephosphorylation of eEF2, in an mTOR independent manner, indicating that signalling via MEK/Erk suffices to cause dephosphorylation of eEF2.

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Submitted date: 22 August 2002
Published date: 6 November 2002
Keywords: translation, elongation, eEF2, MEK, cardiomyocyte, hypertrophy

Identifiers

Local EPrints ID: 56811
URI: http://eprints.soton.ac.uk/id/eprint/56811
ISSN: 0014-5793
PURE UUID: 37b97eeb-c6c7-4636-a3a0-b68bf88ec7e3

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Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

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Contributors

Author: Lijun Wang
Author: Christopher G. Proud

University divisions

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