The University of Southampton
University of Southampton Institutional Repository

The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease

Record type: Article

Systemic inflammation is associated with sickness behaviour and signals pass from the blood to the brain via macrophage populations associated with the brain, the perivascular macrophages and the microglia. The amplitude, or gain, of this transduction process is critically dependent on the state of activation of these macrophages. In chronic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, or prion disease the pathology is associated with a highly atypical inflammatory response, characterised by the activation of the macrophage populations in the brain: the cells are primed. Recent evidence suggests that systemic inflammation may impact on local inflammation in the diseased brain leading to exaggerated synthesis of inflammatory cytokines and other mediators in the brain, which may in turn influence behaviour. These interactions suggest that systemic infections, or indeed any systemic challenge that promotes a systemic inflammatory response, may contribute to the outcome or progression of chronic neurodegenerative disease.

Full text not available from this repository.

Citation

Perry, V.Hugh (2004) The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease Brain, Behavior and Immunity, 18, (5), pp. 407-413. (doi:10.1016/j.bbi.2004.01.004).

More information

Published date: 1 September 2004
Keywords: inflammation, neurodegeneration, macrophage, microglia, infection, sickness, Alzheimer's, Parkinson

Identifiers

Local EPrints ID: 56813
URI: http://eprints.soton.ac.uk/id/eprint/56813
ISSN: 0889-1591
PURE UUID: 2b2919a6-0d98-43d6-ac2a-6456f1563e50

Catalogue record

Date deposited: 07 Aug 2008
Last modified: 17 Jul 2017 14:30

Export record

Altmetrics


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×