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Is crustacean hyperglycaemic hormone precursor-related peptide a circulating neurohormone in crabs?

Wilcockson, David C., Chung, J. Sook and Webster, Simon G. (2002) Is crustacean hyperglycaemic hormone precursor-related peptide a circulating neurohormone in crabs? Cell and Tissue Research, 307, (1), pp. 129-138. (doi:10.1007/s00441-001-0469-8).

Record type: Article


Sites of synthesis and release patterns of crustacean hyperglycaemic hormone precursor-related peptide (CPRP) were investigated with those of crustacean hyperglycaemic hormone (cHH), in order to determine whether this precursor-related peptide satisfies certain criteria necessary for its definition as a secretable, circulating hormone. Using the edible crab, Cancer pagurus, sites of CPRP synthesis were determined by immunohistochemistry and release patterns of both peptides were determined in vivo and in vitro by radioimmunoassay of haemolymph and eyestalk superfusates. Both peptides were co-released from sinus glands (SGs) following potassium-evoked depolarization of isolated eyestalk preparations. However, stress-evoked in vivo release resulted in apparent non-stoichiometric circulating peptide profiles. This phenomenon is explained by notable differences in clearance rates of the peptides in haemolymph. In contrast to cHH, CPRP is very slowly degraded in vivo. Although CPRP is clearly a circulating peptide, whose release is concomitant with that of cHH, physiologically pertinent roles for this molecule remain to be discovered.

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Submitted date: 23 April 2001
Published date: January 2002
Keywords: crustacean, precursor, peptide, neurohormone, Cancer pagurus (Crustacea)


Local EPrints ID: 58168
ISSN: 0302-766X
PURE UUID: 0496c263-ac22-4325-aa45-c2edae620c32

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Date deposited: 12 Aug 2008
Last modified: 17 Jul 2017 14:27

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Author: David C. Wilcockson
Author: J. Sook Chung
Author: Simon G. Webster

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