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Compound optimal designs for percentile estimation in dose-response models with restricted design intervals

Biedermann, Stefanie, Dette, Holger and Zhu, Wei (2007) Compound optimal designs for percentile estimation in dose-response models with restricted design intervals Journal of Statistical Planning and Inference, 137, (12), pp. 3838-3847. (doi:10.1016/j.jspi.2007.04.003).

Record type: Article

Abstract

In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results hold true for most of the commonly applied link functions with respect to the model under consideration.

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Published date: 2007
Keywords: dose-response model, link function, percentile estimation, compound optimal design, a-optimality
Organisations: Statistics

Identifiers

Local EPrints ID: 58642
URI: http://eprints.soton.ac.uk/id/eprint/58642
ISSN: 0378-3758
PURE UUID: 4ad13ff8-dd47-4e5f-af79-3e85a38973b8

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Date deposited: 19 Aug 2008
Last modified: 17 Jul 2017 14:26

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Contributors

Author: Holger Dette
Author: Wei Zhu

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