TAP deficiency syndrome: chronic rhinosinusitis and conductive hearing loss
TAP deficiency syndrome: chronic rhinosinusitis and conductive hearing loss
Nose-ear-throat manifestations of immunodeficiency disorders represent a diagnostic challenge for clinicians as these diseases often constitute the initial sign for connective disorders or autoimmune disease. The history of chronic rhinosinusitis and conductive hearing loss is often non specific. Therefore attention to an HLA class I deficiency must be considered if the disease has not been diagnosed on routine examination. One of the syndromes is due to a defective TAP complex, the peptide transporter complex associated with antigen presentation. Herein, we report two sisters with TAP-deficiency. The treatment of choice for TAP-deficient patients is conservative.
immunodeficiency, tap-deficiency, chronic rhinosinusitis, ear
1289-1292
Caversaccio, Marco
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Bonel, Harald Marcel
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Carter, Rachel
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Williams, Anthony P.
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Gadola, Stephan D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
October 2008
Caversaccio, Marco
c60a62c6-f94a-4221-8e7a-954d68deec30
Bonel, Harald Marcel
7d3af310-412b-4c7d-ba15-bebb1c9b2d7a
Carter, Rachel
8199d829-6dc4-4b09-b58e-a7757d40dacf
Williams, Anthony P.
9dd1e3e0-056f-4014-b8ba-a68b21b90def
Gadola, Stephan D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Caversaccio, Marco, Bonel, Harald Marcel, Carter, Rachel, Williams, Anthony P. and Gadola, Stephan D.
(2008)
TAP deficiency syndrome: chronic rhinosinusitis and conductive hearing loss.
European Archives of Oto-Rhino-Laryngology, 265 (10), .
(doi:10.1007/s00405-008-0610-3).
Abstract
Nose-ear-throat manifestations of immunodeficiency disorders represent a diagnostic challenge for clinicians as these diseases often constitute the initial sign for connective disorders or autoimmune disease. The history of chronic rhinosinusitis and conductive hearing loss is often non specific. Therefore attention to an HLA class I deficiency must be considered if the disease has not been diagnosed on routine examination. One of the syndromes is due to a defective TAP complex, the peptide transporter complex associated with antigen presentation. Herein, we report two sisters with TAP-deficiency. The treatment of choice for TAP-deficient patients is conservative.
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Published date: October 2008
Keywords:
immunodeficiency, tap-deficiency, chronic rhinosinusitis, ear
Identifiers
Local EPrints ID: 59281
URI: http://eprints.soton.ac.uk/id/eprint/59281
ISSN: 0937-4477
PURE UUID: e4726bed-5b43-4db0-a0dd-ff35a774b251
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Date deposited: 05 Sep 2008
Last modified: 15 Mar 2024 11:15
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Contributors
Author:
Marco Caversaccio
Author:
Harald Marcel Bonel
Author:
Rachel Carter
Author:
Anthony P. Williams
Author:
Stephan D. Gadola
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