The University of Southampton
University of Southampton Institutional Repository

CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo.

de Nada, P., Chenivesse, C., Gilet, J., Porte, H., Vorng, H., Chang, Y., Walls, A.F., Wallaert, B., Tonnel, A.B., Tsicopoulos, A. and Zerwes, H.G. (2006) CCR5 usage by CCL5 induces a selective leukocyte recruitment in human skin xenografts in vivo. Journal of Investigative Dermatology, 126, (9), pp. 2057-2064. (doi:10.1038/sj.jid.5700369).

Record type: Article


CCR5 is one of the major inflammatory chemokine receptors with potential therapeutical applications in humans. However, the redundancy of chemokines and their receptors, and the species specificity of chemokine receptor antagonists pose challenges to understanding of the role they play in pharmacological situations. To address this question, we used a humanized severe combined immunodeficient mouse model grafted with human skin and autologous leukocytes, and evaluated the effect of a blocking antibody against human CCR5, on CCL5-induced cutaneous leukocyte recruitment in vivo. At baseline, CCL5 induced a significant recruitment of T cells mainly of the memory phenotype, of monocytes/macrophages, eosinophils, and IFN-gamma(+) but not IL-4(+) and IL-5(+) cells. In vivo, anti-CCR5 antibody was able to almost completely inhibit the recruitment of monocytes/macrophages and T-helper (Th)1-type cells to inhibit partially the attraction of memory T cells, but had no effect on eosinophil infiltration, although all these cell types express other CCL5 binding chemokine receptors than CCR5. These results indicate that the in vivo environment regulates target cell specificity of CCL5 leading to differential cell recruitment, suggesting that antagonizing CCR5 receptor may be of therapeutic value in diseases such as acquired immuno deficiency syndrome, where CCL5/CCR5, monocytes, and Th1-type cells play a predominant role.

Full text not available from this repository.

More information

Published date: 15 June 2006


Local EPrints ID: 59286
ISSN: 0022-202X
PURE UUID: 7e53bda8-bb8c-4708-8904-71410f4e769d

Catalogue record

Date deposited: 02 Sep 2008
Last modified: 17 Jul 2017 14:24

Export record



Author: P. de Nada
Author: C. Chenivesse
Author: J. Gilet
Author: H. Porte
Author: H. Vorng
Author: Y. Chang
Author: A.F. Walls
Author: B. Wallaert
Author: A.B. Tonnel
Author: A. Tsicopoulos
Author: H.G. Zerwes

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.