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Renal hepatitis C in the absence of detectable serum or hepatic virus

Renal hepatitis C in the absence of detectable serum or hepatic virus
Renal hepatitis C in the absence of detectable serum or hepatic virus
We report an apparently unique case where hepatitis C virus (HCV) RNA was identified in renal tissue from a patient with membranoproliferative glomerulonephritis and treated chronic hepatitis C, despite the absence of detectable virus in the serum or liver (COBAS Amplicor qualitative assay, lower limit of detection 50 IU/ml). The implications of this finding are discussed, with particular reference to current concepts regarding 'occult' hepatitis C infection.
glomerulonephritis, hepatitis C, polymerase chain reaction
1478-3223
889-891
Fowell, Andrew J.
d257096a-d4a5-43c0-aa52-51c5e8e4595e
Sheron, Nicholas
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Rosenberg, William M.C.
e9bcd469-ba64-4507-8c7f-145cd9ed2ba3
Fowell, Andrew J.
d257096a-d4a5-43c0-aa52-51c5e8e4595e
Sheron, Nicholas
cbf852e3-cfaa-43b2-ab99-a954d96069f1
Rosenberg, William M.C.
e9bcd469-ba64-4507-8c7f-145cd9ed2ba3

Fowell, Andrew J., Sheron, Nicholas and Rosenberg, William M.C. (2008) Renal hepatitis C in the absence of detectable serum or hepatic virus. Liver International, 28 (6), 889-891. (doi:10.1111/j.1478-3231.2008.01672.x). (PMID:18647143)

Record type: Article

Abstract

We report an apparently unique case where hepatitis C virus (HCV) RNA was identified in renal tissue from a patient with membranoproliferative glomerulonephritis and treated chronic hepatitis C, despite the absence of detectable virus in the serum or liver (COBAS Amplicor qualitative assay, lower limit of detection 50 IU/ml). The implications of this finding are discussed, with particular reference to current concepts regarding 'occult' hepatitis C infection.

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More information

Published date: July 2008
Keywords: glomerulonephritis, hepatitis C, polymerase chain reaction

Identifiers

Local EPrints ID: 59295
URI: http://eprints.soton.ac.uk/id/eprint/59295
DOI: doi:10.1111/j.1478-3231.2008.01672.x
ISSN: 1478-3223
PURE UUID: 33cf6710-2616-405b-96ab-f8e190643408
ORCID for Nicholas Sheron: ORCID iD orcid.org/0000-0001-5232-8292

Catalogue record

Date deposited: 03 Sep 2008
Last modified: 15 Mar 2024 11:15

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Contributors

Author: Andrew J. Fowell
Author: Nicholas Sheron ORCID iD
Author: William M.C. Rosenberg

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