The epithelium takes centre stage in asthma and atopic dermatitis.
The epithelium takes centre stage in asthma and atopic dermatitis.
Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.
248-251
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
June 2007
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holgate, Stephen T.
(2007)
The epithelium takes centre stage in asthma and atopic dermatitis.
Trends in Immunology, 28 (6), .
(doi:10.1016/j.it.2007.04.007).
Abstract
Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.
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Published date: June 2007
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Local EPrints ID: 59322
URI: http://eprints.soton.ac.uk/id/eprint/59322
ISSN: 1471-4906
PURE UUID: 4974d635-a0ee-4705-9c88-a8cdeb32db87
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Date deposited: 02 Sep 2008
Last modified: 15 Mar 2024 11:15
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