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The epithelium takes centre stage in asthma and atopic dermatitis.

The epithelium takes centre stage in asthma and atopic dermatitis.
The epithelium takes centre stage in asthma and atopic dermatitis.
Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.
1471-4906
248-251
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Holgate, Stephen T. (2007) The epithelium takes centre stage in asthma and atopic dermatitis. Trends in Immunology, 28 (6), 248-251. (doi:10.1016/j.it.2007.04.007).

Record type: Article

Abstract

Asthma and atopic dermatitis are epithelial disorders in which T helper 2 (Th2)-type inflammation has a prominent role. Thymic stromal lymphopoietin (TSLP) is a cytokine produced by the skin and airway epithelium that is capable of directing dendritic cells towards a Th2 response, thereby providing an essential link between epithelial cell activation and allergic-type inflammation. In addition, TSLP can interact directly with mast cells to initiate Th2 cytokine production to also provide a non-T cell route to mediate its pro-allergic effects. Induction of TSLP production occurs through the activation of epithelial Toll-like receptors to provide an important new link between innate immunity and allergic disease.

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Published date: June 2007

Identifiers

Local EPrints ID: 59322
URI: http://eprints.soton.ac.uk/id/eprint/59322
ISSN: 1471-4906
PURE UUID: 4974d635-a0ee-4705-9c88-a8cdeb32db87

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Date deposited: 02 Sep 2008
Last modified: 15 Mar 2024 11:15

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