Treatment strategies for allergy and asthma
Treatment strategies for allergy and asthma
Allergic diseases have reached epidemic proportions worldwide. An understanding of the cellular and soluble mediators that are involved in allergic inflammatory responses not only helps in understanding the mechanisms of current treatments, but is also important for the identification of new targets that are amenable to both small-molecule and biological interventions. There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development.
218-230
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Polosa, Riccardo.
fe9e810d-40fa-4d8e-96af-0af2b183daf0
March 2008
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Polosa, Riccardo.
fe9e810d-40fa-4d8e-96af-0af2b183daf0
Holgate, Stephen T. and Polosa, Riccardo.
(2008)
Treatment strategies for allergy and asthma.
Nature Reviews Immunology, 8 (3), .
(doi:10.1038/nri2262).
(PMID:18274559)
Abstract
Allergic diseases have reached epidemic proportions worldwide. An understanding of the cellular and soluble mediators that are involved in allergic inflammatory responses not only helps in understanding the mechanisms of current treatments, but is also important for the identification of new targets that are amenable to both small-molecule and biological interventions. There is now considerable optimism with regards to tackling the allergy epidemic in light of improvements in systemic and mucosal allergen-specific immunotherapy, the identification of key cytokines and their receptors that drive T-helper-2-cell polarization, a clearer understanding of the pathways of leukocyte recruitment and the signalling pathways that are involved in cell activation and mediator secretion, and new approaches to vaccine development.
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Published date: March 2008
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Local EPrints ID: 59326
URI: http://eprints.soton.ac.uk/id/eprint/59326
ISSN: 1474-1733
PURE UUID: 57cb189a-9627-4b97-bd2b-c502135640b9
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Date deposited: 03 Sep 2008
Last modified: 15 Mar 2024 11:15
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Author:
Riccardo. Polosa
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