Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial]
Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial]
Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.
immune response, inflammatory bowel diseases, intestine, macrophages, matrix metalloproteinase, tissue inflammation
386-388
Pender, Sylvia L.F.
62528b03-ec42-41bb-80fe-48454c2c5242
Li, C.K.F.
39e466df-ca1c-4bd4-8274-eeab78c4bf79
Di Sabatino, A.
7e2802bd-ff3d-4578-862d-1d9c524b78a4
MacDonald, T.T.
171334aa-638a-42b0-99f6-e860e2f0ca45
Buckley, M.G.
65d8ab7d-a21c-4d2c-b809-183dbdb3c4cd
August 2006
Pender, Sylvia L.F.
62528b03-ec42-41bb-80fe-48454c2c5242
Li, C.K.F.
39e466df-ca1c-4bd4-8274-eeab78c4bf79
Di Sabatino, A.
7e2802bd-ff3d-4578-862d-1d9c524b78a4
MacDonald, T.T.
171334aa-638a-42b0-99f6-e860e2f0ca45
Buckley, M.G.
65d8ab7d-a21c-4d2c-b809-183dbdb3c4cd
Pender, Sylvia L.F., Li, C.K.F., Di Sabatino, A., MacDonald, T.T. and Buckley, M.G.
(2006)
Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial].
Annals of the New York Academy of Sciences, 1072, .
(doi:10.1196/annals.1326.019).
Abstract
Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.
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Published date: August 2006
Keywords:
immune response, inflammatory bowel diseases, intestine, macrophages, matrix metalloproteinase, tissue inflammation
Identifiers
Local EPrints ID: 59386
URI: http://eprints.soton.ac.uk/id/eprint/59386
ISSN: 0077-8923
PURE UUID: d227c0f5-71cf-4bd7-9dc4-985cc47995c3
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Date deposited: 03 Sep 2008
Last modified: 16 Mar 2024 03:19
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Contributors
Author:
C.K.F. Li
Author:
A. Di Sabatino
Author:
T.T. MacDonald
Author:
M.G. Buckley
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