Mechanisms and mediators of nasal symptoms in non-allergic rhinitis

Salib, R.J., Harries, P.G ., Nair, S.B. and Howarth, P.H. (2008) Mechanisms and mediators of nasal symptoms in non-allergic rhinitis Clinical & Experimental Allergy, 38, (3), pp. 393-404. (doi:10.1111/j.1365-2222.2007.02926.x). (PMID:18201248).


Full text not available from this repository.


Non-allergic rhinitis may be a contributing factor in up to 60% of rhinitis patients and a sole contributor in a quarter. It is a highly heterogeneous condition with poorly understood pathophysiological mechanisms. Compelling evidence is emerging of a localized nasal mucosal allergic response in some non-allergic rhinitic subjects in the absence of systemic atopy. While the inflammatory disease pathway in non-allergic rhinitis may share some of the features of its allergic counterpart, overall the mechanisms remain unclear, and there are likely to be differences. In particular, symptoms of nasal congestion and rhinorrhoea tend to be more prominent and persistent in non-allergic rhinitic patients compared with allergic rhinitis. Our aim is to review the literature relating to mechanisms and mediators of nasal symptoms in non-allergic rhinitis. Better understanding of the underlying pathophysiological basis should enable the development of more accurate testing, and better targeted therapeutic options in the future.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1111/j.1365-2222.2007.02926.x
ISSNs: 0954-7894 (print)

ePrint ID: 59404
Date :
Date Event
14 January 2008Published
Date Deposited: 03 Sep 2008
Last Modified: 16 Apr 2017 17:34
Further Information:Google Scholar

Actions (login required)

View Item View Item