The University of Southampton
University of Southampton Institutional Repository

Requirements for FGF3 and FGF10 during inner ear formation

Alvarez, Yolanda, Alonso, Maria Teresa, Vendrell, Victor, Zelarayan, Laura Cecilia, Chamero, Pablo, Theil, Thomas, Bösl, Michael R., Kato, Shigeaki, Maconochie, Mark, Riethmacher, Dieter and Schimmang, Thomas (2003) Requirements for FGF3 and FGF10 during inner ear formation Development, 130, (25), pp. 6329-6338. (doi:10.1242/dev.00881).

Record type: Article


Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and organogenesis in vertebrates. FGF3 is expressed in the developing hindbrain and has been shown to be involved in inner ear development of different vertebrate species, including zebrafish, Xenopus, chick and mouse. In the mouse, insertion of a neomycin resistance gene into the Fgf3 gene via homologous recombination results in severe developmental defects during differentiation of the otic vesicle. We have addressed the precise roles of FGF3 and other FGF family members during formation of the murine inner ear using both loss- and gain-of-function experiments. We generated a new mutant allele lacking the entire FGF3-coding region but surprisingly found no evidence for severe defects either during inner ear development or in the mature sensory organ, suggesting the functional involvement of other FGF family members during its formation. Ectopic expression of FGF10 in the developing hindbrain of transgenic mice leads to the formation of ectopic vesicles, expressing some otic marker genes and thus indicating a role for FGF10 during otic vesicle formation. Expression analysis of FGF10 during mouse embryogenesis reveals a highly dynamic pattern of expression in the developing hindbrain, partially overlapping with FGF3 expression and coinciding with formation of the inner ear. However, FGF10 mutant mice have been reported to display only mild defects during inner ear differentiation. We thus created double mutant mice for FGF3 and FGF10, which form severely reduced otic vesicles, suggesting redundant roles of these FGFs, acting in combination as neural signals for otic vesicle formation

Full text not available from this repository.

More information

Published date: 22 December 2003
Keywords: organogenesis, germany, proto-oncogene proteins, genetics, family, knockout, gene deletion, embryology, vertebrates, chick embryo, growth, proteins, animals, inner, xenopus proteins, zebrafish proteins, mice, role, research support, deficiency, expression, physiology, fibroblast growth factor 10, combination, chickens, research, congenital abnormalities, xenopus, comparative study, differentiation, zebrafish, fibroblast growth factors, ear, analysis, fibroblast growth factor 3, genes, protein


Local EPrints ID: 59449
ISSN: 1477-9129
PURE UUID: 90b81ce9-2ba7-4e7e-babf-b7b8d212ef26

Catalogue record

Date deposited: 05 Sep 2008
Last modified: 17 Jul 2017 14:24

Export record



Author: Yolanda Alvarez
Author: Maria Teresa Alonso
Author: Victor Vendrell
Author: Laura Cecilia Zelarayan
Author: Pablo Chamero
Author: Thomas Theil
Author: Michael R. Bösl
Author: Shigeaki Kato
Author: Mark Maconochie
Author: Thomas Schimmang

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.