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Role of the JAK-STAT pathway in myocardial injury

Role of the JAK-STAT pathway in myocardial injury
Role of the JAK-STAT pathway in myocardial injury
Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy.
pathology, therapy, prevention, control, humans, physiopathology, hypertrophy, molecular biology, cardiomegaly, injuries, child, myocardial, human, physiology, myocardial reperfusion injury, myocardial infarction, biology, animals, cardiovascular, myocardium, pathologic, review, role, stat transcription factors, virology, etiology, london, heart diseases, janus kinases, myocarditis, transcription factors, apoptosis, ischemic preconditioning, neovascularization, research, research support, models, health
1471-4914
82-89
Barry, Seán P.
be2c2533-9d53-4421-8acc-18c078e18452
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3
Barry, Seán P.
be2c2533-9d53-4421-8acc-18c078e18452
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Latchman, David S.
71e9db7c-9075-4b49-afac-6413085378db
Stephanou, Anastasis
e9d502e8-693c-4458-a3c6-5e2844665db3

Barry, Seán P., Townsend, Paul A., Latchman, David S. and Stephanou, Anastasis (2007) Role of the JAK-STAT pathway in myocardial injury. Trends in Molecular Medicine, 13 (2), 82-89. (doi:10.1016/j.molmed.2006.12.002).

Record type: Article

Abstract

Cardiovascular pathologies are an enormous burden in human health and despite the vast amount of research; the molecular mechanisms and pathways that control the underlying pathologies are still not fully appreciated. The Janus kinase (JAK)-signal transducers and activators of transcription (STAT) pathway has recently been shown to be an integral part of the response of the myocardium to various cardiac insults, including myocardial infarction, oxidative damage, myocarditis, hypertrophy and remodeling, in addition to having a prominent role in cardioprotective therapies such as ischaemic preconditioning. Here, recent advances in the understanding of how the JAK-STAT pathway orchestrates the response to cellular damage in the myocardium are discussed, along with the potential benefits and challenges in manipulating this pathway in cardiovascular therapy.

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More information

Published date: February 2007
Keywords: pathology, therapy, prevention, control, humans, physiopathology, hypertrophy, molecular biology, cardiomegaly, injuries, child, myocardial, human, physiology, myocardial reperfusion injury, myocardial infarction, biology, animals, cardiovascular, myocardium, pathologic, review, role, stat transcription factors, virology, etiology, london, heart diseases, janus kinases, myocarditis, transcription factors, apoptosis, ischemic preconditioning, neovascularization, research, research support, models, health

Identifiers

Local EPrints ID: 59490
URI: https://eprints.soton.ac.uk/id/eprint/59490
ISSN: 1471-4914
PURE UUID: 33a420b8-7e8e-4923-9940-d2668c581e62

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Date deposited: 04 Sep 2008
Last modified: 13 Mar 2019 20:30

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Contributors

Author: Seán P. Barry
Author: Paul A. Townsend
Author: David S. Latchman
Author: Anastasis Stephanou

University divisions

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