Embryonic stem cells to beta-cells by understanding pancreas development
Embryonic stem cells to beta-cells by understanding pancreas development
Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet transplantation suggests cell replacement therapies may offer a curative strategy. However, cadaver islets are of insufficient number for this to become a widespread treatment. To address this deficiency, the production of beta-cells from pluripotent stem cells offers an ambitious far-sighted opportunity. Recent progress in generating insulin-producing cells from embryonic stem cells has shown promise, highlighting the potential of trying to mimic normal developmental pathways. Here, we provide an overview of the current methodology that has been used to differentiate stem cells toward a beta-cell fate. Parallels are drawn with what is known about normal development, especially regarding the human pancreas
stem cell, beta-cell, pancreas, human, mouse, diabetes
86-94
Best, Marie
4ab7bbcf-864e-446c-b911-ac423e34909d
Carroll, Michael
527c3628-58dc-4502-98e6-d03983beac9e
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Piper Hanley, Karen
f11a1076-ad7d-446e-bd59-96814475e06f
June 2008
Best, Marie
4ab7bbcf-864e-446c-b911-ac423e34909d
Carroll, Michael
527c3628-58dc-4502-98e6-d03983beac9e
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Piper Hanley, Karen
f11a1076-ad7d-446e-bd59-96814475e06f
Best, Marie, Carroll, Michael, Hanley, Neil A. and Piper Hanley, Karen
(2008)
Embryonic stem cells to beta-cells by understanding pancreas development.
Molecular and Cellular Endocrinology, 288 (1-2), .
(doi:10.1016/j.mce.2008.03.008).
(PMID:18487011)
Abstract
Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet transplantation suggests cell replacement therapies may offer a curative strategy. However, cadaver islets are of insufficient number for this to become a widespread treatment. To address this deficiency, the production of beta-cells from pluripotent stem cells offers an ambitious far-sighted opportunity. Recent progress in generating insulin-producing cells from embryonic stem cells has shown promise, highlighting the potential of trying to mimic normal developmental pathways. Here, we provide an overview of the current methodology that has been used to differentiate stem cells toward a beta-cell fate. Parallels are drawn with what is known about normal development, especially regarding the human pancreas
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Published date: June 2008
Keywords:
stem cell, beta-cell, pancreas, human, mouse, diabetes
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Local EPrints ID: 59503
URI: http://eprints.soton.ac.uk/id/eprint/59503
PURE UUID: 77dc2938-5adb-426d-a083-c6a7e1f643a9
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Date deposited: 09 Sep 2008
Last modified: 15 Mar 2024 11:16
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Contributors
Author:
Marie Best
Author:
Michael Carroll
Author:
Neil A. Hanley
Author:
Karen Piper Hanley
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