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Embryonic stem cells to beta-cells by understanding pancreas development

Embryonic stem cells to beta-cells by understanding pancreas development
Embryonic stem cells to beta-cells by understanding pancreas development
Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet transplantation suggests cell replacement therapies may offer a curative strategy. However, cadaver islets are of insufficient number for this to become a widespread treatment. To address this deficiency, the production of beta-cells from pluripotent stem cells offers an ambitious far-sighted opportunity. Recent progress in generating insulin-producing cells from embryonic stem cells has shown promise, highlighting the potential of trying to mimic normal developmental pathways. Here, we provide an overview of the current methodology that has been used to differentiate stem cells toward a beta-cell fate. Parallels are drawn with what is known about normal development, especially regarding the human pancreas
stem cell, beta-cell, pancreas, human, mouse, diabetes
86-94
Best, Marie
4ab7bbcf-864e-446c-b911-ac423e34909d
Carroll, Michael
527c3628-58dc-4502-98e6-d03983beac9e
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Piper Hanley, Karen
f11a1076-ad7d-446e-bd59-96814475e06f
Best, Marie
4ab7bbcf-864e-446c-b911-ac423e34909d
Carroll, Michael
527c3628-58dc-4502-98e6-d03983beac9e
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Piper Hanley, Karen
f11a1076-ad7d-446e-bd59-96814475e06f

Best, Marie, Carroll, Michael, Hanley, Neil A. and Piper Hanley, Karen (2008) Embryonic stem cells to beta-cells by understanding pancreas development. Molecular and Cellular Endocrinology, 288 (1-2), 86-94. (doi:10.1016/j.mce.2008.03.008). (PMID:18487011)

Record type: Article

Abstract

Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet transplantation suggests cell replacement therapies may offer a curative strategy. However, cadaver islets are of insufficient number for this to become a widespread treatment. To address this deficiency, the production of beta-cells from pluripotent stem cells offers an ambitious far-sighted opportunity. Recent progress in generating insulin-producing cells from embryonic stem cells has shown promise, highlighting the potential of trying to mimic normal developmental pathways. Here, we provide an overview of the current methodology that has been used to differentiate stem cells toward a beta-cell fate. Parallels are drawn with what is known about normal development, especially regarding the human pancreas

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More information

Published date: June 2008
Keywords: stem cell, beta-cell, pancreas, human, mouse, diabetes

Identifiers

Local EPrints ID: 59503
URI: https://eprints.soton.ac.uk/id/eprint/59503
PURE UUID: 77dc2938-5adb-426d-a083-c6a7e1f643a9

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 13 Mar 2019 20:30

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