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Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia

Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia
Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia
The putative tumour suppressor gene gravin is down-regulated in several solid tumours and is implicated in tumorigenesis. We have evaluated the expression levels of the gravin gene in the CD34(+)/blast cells of a range of myeloid malignancies as compared with controls using real-time quantitative polymerase chain reaction (PCR). Gravin was markedly down-regulated in 41 of 41 patients with acute myeloid leukaemia (AML), nine of 10 patients with myelodysplastic syndromes (MDS) and 33 of 33 patients with chronic myeloid leukaemia (CML), of whom 24 were in blast crisis (BC). We have shown that gravin is consistently down-regulated in the CD34(+)/blast cells of myeloid malignancies and may play a role in the molecular pathogenesis of these disorders.
chronic, metabolism, syndrome, genetics, polymerase chain reaction, dna mutational analysis, research support, humans, neoplasm proteins, acute disease, myeloid, non-u.s.gov't, protein, neoplastic, proteins, leukemia, analysis, pathology, laboratories, cell transformation, down-regulation, antigens, blast crisis, reverse transcriptase polymerase chain reaction, myelodysplastic syndromes, research, patients, cd34, role
0007-1048
508-511
Boultwood, J.
ed4eba17-8291-4cae-b767-524c1c58169c
Pellagatti, A.
93d2306f-6d2f-4969-bae6-1dece7d92be7
Watkins, F.
88844f45-48bd-48df-bdcf-91e807d03e4a
Campbell, L.J.
202f000a-4681-48b9-a686-8acd9e655ab6
Esoof, N.
2e12e799-cafc-4796-b56a-83ecef92808f
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Eagleton, H.
a011be16-3883-4792-9939-5b976f150a3b
Littlewood, T.J.
598e530e-0e9d-46b8-b744-b99e450e80e1
Fidler, C.
5e321bd7-1470-4db1-adf6-1f787a657d11
Wainscoat, J.S.
c6bc44d2-b20c-42b7-8bea-f46a16f9d957
Boultwood, J.
ed4eba17-8291-4cae-b767-524c1c58169c
Pellagatti, A.
93d2306f-6d2f-4969-bae6-1dece7d92be7
Watkins, F.
88844f45-48bd-48df-bdcf-91e807d03e4a
Campbell, L.J.
202f000a-4681-48b9-a686-8acd9e655ab6
Esoof, N.
2e12e799-cafc-4796-b56a-83ecef92808f
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Eagleton, H.
a011be16-3883-4792-9939-5b976f150a3b
Littlewood, T.J.
598e530e-0e9d-46b8-b744-b99e450e80e1
Fidler, C.
5e321bd7-1470-4db1-adf6-1f787a657d11
Wainscoat, J.S.
c6bc44d2-b20c-42b7-8bea-f46a16f9d957

Boultwood, J., Pellagatti, A., Watkins, F., Campbell, L.J., Esoof, N., Cross, N.C., Eagleton, H., Littlewood, T.J., Fidler, C. and Wainscoat, J.S. (2004) Low expression of the putative tumour suppressor gene gravin in chronic myeloid leukaemia, myelodysplastic syndromes and acute myeloid leukaemia. British Journal of Haematology, 126 (4), 508-511. (doi:10.1111/j.1365-2141.2004.05067.x).

Record type: Article

Abstract

The putative tumour suppressor gene gravin is down-regulated in several solid tumours and is implicated in tumorigenesis. We have evaluated the expression levels of the gravin gene in the CD34(+)/blast cells of a range of myeloid malignancies as compared with controls using real-time quantitative polymerase chain reaction (PCR). Gravin was markedly down-regulated in 41 of 41 patients with acute myeloid leukaemia (AML), nine of 10 patients with myelodysplastic syndromes (MDS) and 33 of 33 patients with chronic myeloid leukaemia (CML), of whom 24 were in blast crisis (BC). We have shown that gravin is consistently down-regulated in the CD34(+)/blast cells of myeloid malignancies and may play a role in the molecular pathogenesis of these disorders.

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Published date: 5 July 2004
Keywords: chronic, metabolism, syndrome, genetics, polymerase chain reaction, dna mutational analysis, research support, humans, neoplasm proteins, acute disease, myeloid, non-u.s.gov't, protein, neoplastic, proteins, leukemia, analysis, pathology, laboratories, cell transformation, down-regulation, antigens, blast crisis, reverse transcriptase polymerase chain reaction, myelodysplastic syndromes, research, patients, cd34, role

Identifiers

Local EPrints ID: 59514
URI: http://eprints.soton.ac.uk/id/eprint/59514
ISSN: 0007-1048
PURE UUID: e50cb879-1945-4b5d-822a-c1c764a61dec
ORCID for N.C. Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 03 Sep 2008
Last modified: 07 Oct 2020 01:46

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Contributors

Author: J. Boultwood
Author: A. Pellagatti
Author: F. Watkins
Author: L.J. Campbell
Author: N. Esoof
Author: N.C. Cross ORCID iD
Author: H. Eagleton
Author: T.J. Littlewood
Author: C. Fidler
Author: J.S. Wainscoat

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