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Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity

Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity
Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity
Eosinophil-associated conditions, such as asthma and eosinophilic bronchitis, have been associated with chronic persistent cough, usually responding to corticosteroid therapy. This case study reports a case of persistent cough associated with gastro-oesophageal reflux (GOR) and hypereosinophilia. Treatment of GOR with proton pump inhibitors and fundoplication did not control the cough. However, high dose prednisolone, but not inhaled corticosteroids, did. The presence of the FIP1L1-PDGFRA fusion gene in myeloid cells was confirmed by fluorescence in situ hybridisation analysis using CHIC2 deletion as a surrogate marker. The cough and other disease features were subsequently suppressed by the tyrosine kinase inhibitor, imatinib. This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity
prednisolone, tyrosine, fluorescence, analysis, bronchitis, asthma, syndrome, disease, myeloid cells, london, therapy, hypereosinophilic syndrome, heart, cough, activity, lung, report
0903-1936
230-232
Chung, K. F.
5690488b-509e-4632-ace7-2221fc5b453e
Hew, M.
6d520a70-2bce-46c4-bc81-c450165dc555
Score, J.
ea0db6ef-c17e-4915-b216-ac67c07b26b7
Jones, A. V.
255cbb09-08c6-43f0-afc7-4ec29f073ea8
Reiter, A.
8fc082eb-6b46-4412-86b2-f4c7669f0650
Cross, N. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Bain, B. J.
ab855b9b-8888-4bbb-82cd-3f2d3e2abff7
Chung, K. F.
5690488b-509e-4632-ace7-2221fc5b453e
Hew, M.
6d520a70-2bce-46c4-bc81-c450165dc555
Score, J.
ea0db6ef-c17e-4915-b216-ac67c07b26b7
Jones, A. V.
255cbb09-08c6-43f0-afc7-4ec29f073ea8
Reiter, A.
8fc082eb-6b46-4412-86b2-f4c7669f0650
Cross, N. C. P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Bain, B. J.
ab855b9b-8888-4bbb-82cd-3f2d3e2abff7

Chung, K. F., Hew, M., Score, J., Jones, A. V., Reiter, A., Cross, N. C. P. and Bain, B. J. (2006) Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. European Respiratory Journal, 27 (1), 230-232. (doi:10.1183/09031936.06.00089405).

Record type: Article

Abstract

Eosinophil-associated conditions, such as asthma and eosinophilic bronchitis, have been associated with chronic persistent cough, usually responding to corticosteroid therapy. This case study reports a case of persistent cough associated with gastro-oesophageal reflux (GOR) and hypereosinophilia. Treatment of GOR with proton pump inhibitors and fundoplication did not control the cough. However, high dose prednisolone, but not inhaled corticosteroids, did. The presence of the FIP1L1-PDGFRA fusion gene in myeloid cells was confirmed by fluorescence in situ hybridisation analysis using CHIC2 deletion as a surrogate marker. The cough and other disease features were subsequently suppressed by the tyrosine kinase inhibitor, imatinib. This is the first case of persistent cough caused by hypereosinophilic syndrome characterised by FIP1L1-PDGFRA fusion gene and aberrant tyrosine kinase activity

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More information

Published date: January 2006
Keywords: prednisolone, tyrosine, fluorescence, analysis, bronchitis, asthma, syndrome, disease, myeloid cells, london, therapy, hypereosinophilic syndrome, heart, cough, activity, lung, report

Identifiers

Local EPrints ID: 59576
URI: http://eprints.soton.ac.uk/id/eprint/59576
ISSN: 0903-1936
PURE UUID: d5d76e87-4526-462e-a764-4ebe3f171a46
ORCID for N. C. P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 04 Sep 2008
Last modified: 03 Dec 2019 01:52

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Contributors

Author: K. F. Chung
Author: M. Hew
Author: J. Score
Author: A. V. Jones
Author: A. Reiter
Author: N. C. P. Cross ORCID iD
Author: B. J. Bain

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