Linkage disequilibrium and association mapping: an introduction
Linkage disequilibrium and association mapping: an introduction
The basis for recent developments on the characterization of the linkage-disequilibrium structure of the genome and the application of association mapping to genes for common human diseases is described. Patterns of linkage disequilibrium are now understood, for a number of human populations, in unprecedented detail. This information not only provides a vital resource for the design and execution of powerful association-mapping studies, but opens new avenues of research into the genetic history of human populations and the effects of natural selection, mutation, and recombination on the genomic landscape.
recombination, linkage mapping, linkage disequilibrium, haplotype blocks, selection, case-control study, candidate regions, genome-wide association
9781588296696
1-15
Collins, Andrew R.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
5 February 2008
Collins, Andrew R.
7daa83eb-0b21-43b2-af1a-e38fb36e2a64
Collins, Andrew R.
(2008)
Linkage disequilibrium and association mapping: an introduction.
In,
Collins, Andrew R.
(ed.)
Linkage Disequilibrium and Association Mapping.
(Methods in Molecular Biology, 376)
Totowa, USA.
Humana, .
(doi:10.1007/978-1-59745-389-9_1).
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Abstract
The basis for recent developments on the characterization of the linkage-disequilibrium structure of the genome and the application of association mapping to genes for common human diseases is described. Patterns of linkage disequilibrium are now understood, for a number of human populations, in unprecedented detail. This information not only provides a vital resource for the design and execution of powerful association-mapping studies, but opens new avenues of research into the genetic history of human populations and the effects of natural selection, mutation, and recombination on the genomic landscape.
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Published date: 5 February 2008
Additional Information:
ISSN 1064-3745
Keywords:
recombination, linkage mapping, linkage disequilibrium, haplotype blocks, selection, case-control study, candidate regions, genome-wide association
Identifiers
Local EPrints ID: 59595
URI: http://eprints.soton.ac.uk/id/eprint/59595
ISBN: 9781588296696
ISSN: 1064-3745
PURE UUID: c13c5372-076b-452f-9a14-3b1649c4d953
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Date deposited: 05 Sep 2008
Last modified: 16 Mar 2024 02:42
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Editor:
Andrew R. Collins
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