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Progenitor cells of the testosterone-producing Leydig cells revealed

Progenitor cells of the testosterone-producing Leydig cells revealed
Progenitor cells of the testosterone-producing Leydig cells revealed
The cells responsible for production of the male sex hormone testosterone, the Leydig cells of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during ontogeny and regeneration processes is still a matter of debate. Here, we show that cells of testicular blood vessels, namely vascular smooth muscle cells and pericytes, are the progenitors of Leydig cells. Resembling stem cells of the nervous system, the Leydig cell progenitors are characterized by the expression of nestin. Using an in vivo model to induce and monitor the synchronized generation of a completely new Leydig cell population in adult rats, we demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells which, in addition, rapidly acquire neuronal and glial properties. These findings, shown to be representative also for ontogenetic Leydig cell formation and for the human testis, provide further evidence that cellular components of blood vessels can act as progenitor cells for organogenesis and repair.
1932-6203
935-944
Davidoff, M.S.
0defcab7-28e9-4112-ba7b-51bbb8ec1f7d
Middendorff, R.
3b9713a3-faf4-463c-bf07-19e66065a38d
Enikolopov, G.
d0f4dc08-ec39-4126-968e-77dde241c1ab
Riethmacher, D.
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Holstein, A.F.
b6cbb15d-0752-42df-9b63-d8f8d74c59e4
Muller, D.
292e9569-828d-4ab8-a5da-f6b1df7d5436
Davidoff, M.S.
0defcab7-28e9-4112-ba7b-51bbb8ec1f7d
Middendorff, R.
3b9713a3-faf4-463c-bf07-19e66065a38d
Enikolopov, G.
d0f4dc08-ec39-4126-968e-77dde241c1ab
Riethmacher, D.
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Holstein, A.F.
b6cbb15d-0752-42df-9b63-d8f8d74c59e4
Muller, D.
292e9569-828d-4ab8-a5da-f6b1df7d5436

Davidoff, M.S., Middendorff, R., Enikolopov, G., Riethmacher, D., Holstein, A.F. and Muller, D. (2004) Progenitor cells of the testosterone-producing Leydig cells revealed. PLoS ONE, 167 (5), 935-944. (doi:10.1083/jcb.200409107).

Record type: Article

Abstract

The cells responsible for production of the male sex hormone testosterone, the Leydig cells of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during ontogeny and regeneration processes is still a matter of debate. Here, we show that cells of testicular blood vessels, namely vascular smooth muscle cells and pericytes, are the progenitors of Leydig cells. Resembling stem cells of the nervous system, the Leydig cell progenitors are characterized by the expression of nestin. Using an in vivo model to induce and monitor the synchronized generation of a completely new Leydig cell population in adult rats, we demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells which, in addition, rapidly acquire neuronal and glial properties. These findings, shown to be representative also for ontogenetic Leydig cell formation and for the human testis, provide further evidence that cellular components of blood vessels can act as progenitor cells for organogenesis and repair.

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Published date: December 2004

Identifiers

Local EPrints ID: 59647
URI: http://eprints.soton.ac.uk/id/eprint/59647
ISSN: 1932-6203
PURE UUID: 3d3514aa-40b5-4f7e-9043-370d86df3967
ORCID for D. Riethmacher: ORCID iD orcid.org/0000-0002-4206-5529

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Date deposited: 04 Sep 2008
Last modified: 26 Nov 2019 01:43

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Contributors

Author: M.S. Davidoff
Author: R. Middendorff
Author: G. Enikolopov
Author: D. Riethmacher ORCID iD
Author: A.F. Holstein
Author: D. Muller

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