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Final adult height and body mass index after cure of paediatric Cushing's disease

Davies, J.H., Storr, H.L., Davies, K., Monson, J.P., Besser, G.M., Afshar, F., Plowman, P.N., Grossman, A.B. and Savage, M.O. (2005) Final adult height and body mass index after cure of paediatric Cushing's disease Clinical Endocrinology, 62, (4), pp. 466-472. (doi:10.1111/j.1365-2265.2005.02244.x).

Record type: Article


OBJECTIVE: Linear growth data after cure of paediatric Cushing's disease (CD) have been reported infrequently. We evaluated final adult height (FH) and body mass index (BMI) in a cohort of paediatric patients treated successfully for CD. PATIENTS AND METHODS: Fourteen patients (10 male, age range 6.4-16.6 years) fulfilled the diagnostic criteria for CD. All had had transsphenoidal surgery (TSS), combined with pituitary irradiation (RT) (45 Gy in 25 fractions) in six. All were cured (post-TSS cortisol < 50 nmol/l or mean cortisol post-RT < 150 nmol/l). Subjects analysed had bone ages at diagnosis of < 15 'years' (male) and < 13 'years' (female). RESULTS: At diagnosis, height SDS was [mean (range)]-2.5 (-4.2 to -0.8) and body mass index (BMI) SDS +2.7 (0.8-5.1). Following cure, 13 patients had GH deficiency (peak GH < 20 mU/l) and were treated with hGH (+ GnRH analogue in four). Height SDS at FH (n = 10) or latest assessment (n = 4) was -1.3 (-3.9-0.2) and increased compared to diagnosis (P < 0.01). The difference between final or latest height SDS and target height SDS was -1.2 (-3.3-0.5), that is less (P < 0.01) than the difference between the height SDS at diagnosis and target height SDS of -2.4 (-3.9 to -0.5). At final height or latest assessment, BMI SDS was +1.7 (0.4-6.2), being decreased compared to diagnosis (P < 0.05) but greater than the normal population (P < 0.01). CONCLUSION: Catch-up growth was demonstrated in paediatric patients cured from CD, with the majority achieving FH within target height range. Early diagnosis and treatment of GH deficiency is recommended to achieve optimal long-term growth. Excess adiposity remains a potential long-term complication.

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Published date: April 2005
Keywords: disease, female, pituitary irradiation, agonists, body mass index, cushing syndrome, cohort, cortisol, gonadotropin-releasing hormone, physiopathology, deficiency, radiotherapy, treatment, humans, adult, human, child, growth, statistics, retrospective studies, height, diagnosis, nonparametric, growth hormone, treatment outcome, pituitary gland, patients, endocrinology, male, body height, london, goserelin, bone, human growth hormone, surgery, methods, population, adolescent, therapeutic use


Local EPrints ID: 59657
PURE UUID: 819ea6b8-e664-4cc5-8e75-2868c01d3927

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Date deposited: 04 Sep 2008
Last modified: 17 Jul 2017 14:24

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Author: J.H. Davies
Author: H.L. Storr
Author: K. Davies
Author: J.P. Monson
Author: G.M. Besser
Author: F. Afshar
Author: P.N. Plowman
Author: A.B. Grossman
Author: M.O. Savage

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