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Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster

Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on chromosome 17q23 encoding GH, placental lactogens [chorionic somatomammotropins (CSH)], and placental GH variant in relation to fetal and infant growth and phenotypic features of the metabolic syndrome in subjects aged 59-72 yr from Hertfordshire, UK. Allele groups T, D1, and D2 of a locus herein designated CSH1.01 were examined in relation to GH-CSH single nucleotide polymorphisms and to specific phenotypes. Average birth weights were similar for all genotype groups. Men with T alleles were significantly lighter at 1 yr of age, shorter as adults, and had higher blood pressures, fasting insulin (T/T 66% higher than D2/D2) and triglyceride concentrations, and insulin and glucose concentrations during a glucose tolerance test. Birth weight and 1-yr weight associations with metabolic syndrome traits were independent of the CSH1.01 effects. Common diversity in GH-CSH correlates with low 1-yr weight and with features of the metabolic syndrome in later life. GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome.
0021-972X
5569-5576
Chen, Xiao-He
fd93b896-d8cc-4b0e-a811-c0e6a8ff8308
Day, Ian N. M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
King, Tabitha H. T.
5d31b61f-ddb4-4189-90e1-40355616997e
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Rodriguez, Santiago
f235ea2b-b6f3-45e4-9fc3-5a0383689ed6
Voropanov, Anca
be4c7636-6504-4f96-bf9d-9c180857a9a9
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Sayer, Ava Aihie
6e903985-b4d7-45e4-99f2-8b742d74a399
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Tabassum, Faiza
a4bcd2d6-c576-4e85-8ba4-c3b4bb1ade08
Barker, David J. P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Phillips, David I. W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Chen, Xiao-He
fd93b896-d8cc-4b0e-a811-c0e6a8ff8308
Day, Ian N. M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
King, Tabitha H. T.
5d31b61f-ddb4-4189-90e1-40355616997e
Ye, Shu
132b6474-1927-4f93-80db-2c620a31c1ab
Rodriguez, Santiago
f235ea2b-b6f3-45e4-9fc3-5a0383689ed6
Voropanov, Anca
be4c7636-6504-4f96-bf9d-9c180857a9a9
Syddall, Holly E.
a0181a93-8fc3-4998-a996-7963f0128328
Sayer, Ava Aihie
6e903985-b4d7-45e4-99f2-8b742d74a399
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Tabassum, Faiza
a4bcd2d6-c576-4e85-8ba4-c3b4bb1ade08
Barker, David J. P.
84efdf7a-7c52-45fc-aa16-9647f3743c27
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Phillips, David I. W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6

Chen, Xiao-He, Day, Ian N. M., Gaunt, Tom R., King, Tabitha H. T., Ye, Shu, Rodriguez, Santiago, Voropanov, Anca, Syddall, Holly E., Sayer, Ava Aihie, Dennison, Elaine M., Tabassum, Faiza, Barker, David J. P., Cooper, Cyrus and Phillips, David I. W. (2004) Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. Journal of Clinical Endocrinology & Metabolism, 89 (11), 5569-5576. (doi:10.1210/jc.2004-0152).

Record type: Article

Abstract

Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on chromosome 17q23 encoding GH, placental lactogens [chorionic somatomammotropins (CSH)], and placental GH variant in relation to fetal and infant growth and phenotypic features of the metabolic syndrome in subjects aged 59-72 yr from Hertfordshire, UK. Allele groups T, D1, and D2 of a locus herein designated CSH1.01 were examined in relation to GH-CSH single nucleotide polymorphisms and to specific phenotypes. Average birth weights were similar for all genotype groups. Men with T alleles were significantly lighter at 1 yr of age, shorter as adults, and had higher blood pressures, fasting insulin (T/T 66% higher than D2/D2) and triglyceride concentrations, and insulin and glucose concentrations during a glucose tolerance test. Birth weight and 1-yr weight associations with metabolic syndrome traits were independent of the CSH1.01 effects. Common diversity in GH-CSH correlates with low 1-yr weight and with features of the metabolic syndrome in later life. GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome.

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Published date: November 2004

Identifiers

Local EPrints ID: 59662
URI: http://eprints.soton.ac.uk/id/eprint/59662
ISSN: 0021-972X
PURE UUID: 1e93559c-3220-42c5-9dd2-1396b0a3009c
ORCID for Holly E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for Elaine M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 04 Sep 2008
Last modified: 18 Feb 2021 16:50

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Contributors

Author: Xiao-He Chen
Author: Ian N. M. Day
Author: Tom R. Gaunt
Author: Tabitha H. T. King
Author: Shu Ye
Author: Santiago Rodriguez
Author: Anca Voropanov
Author: Ava Aihie Sayer
Author: Faiza Tabassum
Author: David J. P. Barker
Author: Cyrus Cooper ORCID iD
Author: David I. W. Phillips

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