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ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia

ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia
ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia
Hydroxyurea (HU) has been used for more than 10 years in children severely affected with sickle cell disease (SCD) to reduce the number of painful episodes. Short- to medium-term tolerance of the drug is good.1-3 Concern remains, however, about the long-term safety of the drug and, in particular, its leukemogenic potential. Leukemia has been reported in myelodysplastic syndromes after at least 3 to 4 years of exposure to the drug,4-5 so only long-term studies including significant numbers of patients can resolve concern for SCD. So far, 3 studies on long-term effects of HU in SCD children have been published (Table 1).6-8
in situ hybridization, humans, reverse transcriptase polymerase chain reaction, leukemia, sequence deletion, survival rate, chromosomes, adult, non-u.s.gov't, research support, fluorescence, bcr-abl, myeloid, female, aged, human, 80 and over, fusion proteins, fusion, protein, mortality, pair 9, male, epidemiology, survival, adolescent, chronic, oncogene proteins, letter, base sequence, proteins, genetics, metabolism, middle aged, child
0006-4971
2879-2880
De la Fuente, J.
c2bb43f6-fb28-4116-8a1f-d05c468a06d5
Merx, K.
119693a0-18cb-4474-83d1-776c685ccac8
Steer, E.J.
72d16c6e-56ba-4a02-9f00-8eaf486c96a7
Muller, M.
359678c4-5d02-4ef8-b381-f31238f339d1
Szydlo, R.M.
c94ab689-1fc9-410c-b41f-a6a058c1f81c
Maywald, O.
25866015-e1b5-456d-a200-b33cb51db00f
Berger, U.
440811e1-e1c2-4f54-a435-b6dd61853857
Hehlmann, R.
753d719b-7bf8-4f74-bfdc-6d5d47e5d2c7
Goldman, J.M.
c0abeb85-851b-4680-b28e-e646d94a91f7
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Melo, J.V.
e3ef7550-b67a-458c-af81-5d7dd8fb1306
Hochhaus, A.
4c0b9da4-adfa-4253-8af7-78cec9e9a24f
De la Fuente, J.
c2bb43f6-fb28-4116-8a1f-d05c468a06d5
Merx, K.
119693a0-18cb-4474-83d1-776c685ccac8
Steer, E.J.
72d16c6e-56ba-4a02-9f00-8eaf486c96a7
Muller, M.
359678c4-5d02-4ef8-b381-f31238f339d1
Szydlo, R.M.
c94ab689-1fc9-410c-b41f-a6a058c1f81c
Maywald, O.
25866015-e1b5-456d-a200-b33cb51db00f
Berger, U.
440811e1-e1c2-4f54-a435-b6dd61853857
Hehlmann, R.
753d719b-7bf8-4f74-bfdc-6d5d47e5d2c7
Goldman, J.M.
c0abeb85-851b-4680-b28e-e646d94a91f7
Cross, N.C.
f87650da-b908-4a34-b31b-d62c5f186fe4
Melo, J.V.
e3ef7550-b67a-458c-af81-5d7dd8fb1306
Hochhaus, A.
4c0b9da4-adfa-4253-8af7-78cec9e9a24f

De la Fuente, J., Merx, K., Steer, E.J., Muller, M., Szydlo, R.M., Maywald, O., Berger, U., Hehlmann, R., Goldman, J.M., Cross, N.C., Melo, J.V. and Hochhaus, A. (2001) ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia. Blood, 98 (9), 2879-2880.

Record type: Article

Abstract

Hydroxyurea (HU) has been used for more than 10 years in children severely affected with sickle cell disease (SCD) to reduce the number of painful episodes. Short- to medium-term tolerance of the drug is good.1-3 Concern remains, however, about the long-term safety of the drug and, in particular, its leukemogenic potential. Leukemia has been reported in myelodysplastic syndromes after at least 3 to 4 years of exposure to the drug,4-5 so only long-term studies including significant numbers of patients can resolve concern for SCD. So far, 3 studies on long-term effects of HU in SCD children have been published (Table 1).6-8

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More information

Published date: 2001
Keywords: in situ hybridization, humans, reverse transcriptase polymerase chain reaction, leukemia, sequence deletion, survival rate, chromosomes, adult, non-u.s.gov't, research support, fluorescence, bcr-abl, myeloid, female, aged, human, 80 and over, fusion proteins, fusion, protein, mortality, pair 9, male, epidemiology, survival, adolescent, chronic, oncogene proteins, letter, base sequence, proteins, genetics, metabolism, middle aged, child

Identifiers

Local EPrints ID: 59672
URI: https://eprints.soton.ac.uk/id/eprint/59672
ISSN: 0006-4971
PURE UUID: ce7b0365-d262-4c39-95dd-ed55c74abb68
ORCID for N.C. Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 02 Sep 2008
Last modified: 19 Jul 2019 18:39

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Contributors

Author: J. De la Fuente
Author: K. Merx
Author: E.J. Steer
Author: M. Muller
Author: R.M. Szydlo
Author: O. Maywald
Author: U. Berger
Author: R. Hehlmann
Author: J.M. Goldman
Author: N.C. Cross ORCID iD
Author: J.V. Melo
Author: A. Hochhaus

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