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Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells

Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells
Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells
Hypoxic inhibition of O2-sensitive K+ channels plays a key role in mediating numerous cellular responses which counteract the deleterious effects of hypoxia. In type I cells of the carotid body (CB), a neurosecretory organ that responds to hypoxia by releasing neurotransmitters from specialized O2-sensing type I cells onto sensory nerve endings, hypoxic inhibition of K+ channels underlies the membrane depolarisation (Lopez-Barneo et al., 1988) that stimulates Ca2+ entry and neurotransmitter release (Urena et al., 1994). In other neurosecretory cells, such as those located in the neuroepithelial cell bodies of the lung (Youngson et al., 1993) and the adrenal medulla (Thompson and Nurse, 1998), hypoxic inhibition of K+ channels provides a critical link between O2 levels and the appropriate cellular responses.
protein, tandem pore domain, recombinant proteins, human, cell hypoxia, genetics, physiology, proteins, potassium channels, metabolism, research, gene expression regulation, cell line
0387313109
203-208
Springer
Fearon, Ian M.
14bdb67c-b799-407f-8dc0-86fbc08920c2
Campanucci, Veronica A.
d48b8d17-81b6-4cd3-b2f9-c4f587c1038d
Brown, Stephen T.
222a8ad2-9aca-4da2-a254-65d619c3ebff
Hudasek, Kristin
2fafcad7-f5cd-4b09-a609-bdafa5239a4c
O'Kelly, Ita M.
b287e528-8464-4423-aeed-d5ce846fbb4d
Nurse, Colin A.
9b36ed5e-0181-48e5-a7c5-71bbe05da930
Fearon, Ian M.
14bdb67c-b799-407f-8dc0-86fbc08920c2
Campanucci, Veronica A.
d48b8d17-81b6-4cd3-b2f9-c4f587c1038d
Brown, Stephen T.
222a8ad2-9aca-4da2-a254-65d619c3ebff
Hudasek, Kristin
2fafcad7-f5cd-4b09-a609-bdafa5239a4c
O'Kelly, Ita M.
b287e528-8464-4423-aeed-d5ce846fbb4d
Nurse, Colin A.
9b36ed5e-0181-48e5-a7c5-71bbe05da930

Fearon, Ian M., Campanucci, Veronica A., Brown, Stephen T., Hudasek, Kristin, O'Kelly, Ita M. and Nurse, Colin A. (2006) Acute hypoxic regulation of recombinant THIK-1 stably expressed in HEK293 cells. In, The Arterial Chemoreceptors. (Advances in Experimental Medicine and Biology, 580) USA. Springer, pp. 203-208. (doi:10.1007/0-387-31311-7_31).

Record type: Book Section

Abstract

Hypoxic inhibition of O2-sensitive K+ channels plays a key role in mediating numerous cellular responses which counteract the deleterious effects of hypoxia. In type I cells of the carotid body (CB), a neurosecretory organ that responds to hypoxia by releasing neurotransmitters from specialized O2-sensing type I cells onto sensory nerve endings, hypoxic inhibition of K+ channels underlies the membrane depolarisation (Lopez-Barneo et al., 1988) that stimulates Ca2+ entry and neurotransmitter release (Urena et al., 1994). In other neurosecretory cells, such as those located in the neuroepithelial cell bodies of the lung (Youngson et al., 1993) and the adrenal medulla (Thompson and Nurse, 1998), hypoxic inhibition of K+ channels provides a critical link between O2 levels and the appropriate cellular responses.

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More information

Published date: 2006
Keywords: protein, tandem pore domain, recombinant proteins, human, cell hypoxia, genetics, physiology, proteins, potassium channels, metabolism, research, gene expression regulation, cell line

Identifiers

Local EPrints ID: 59717
URI: http://eprints.soton.ac.uk/id/eprint/59717
ISBN: 0387313109
PURE UUID: 7d72e890-06cc-48b8-9258-e3910c9ebff6

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Date deposited: 08 Sep 2008
Last modified: 15 Mar 2024 11:17

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Contributors

Author: Ian M. Fearon
Author: Veronica A. Campanucci
Author: Stephen T. Brown
Author: Kristin Hudasek
Author: Ita M. O'Kelly
Author: Colin A. Nurse

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