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Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis
Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis
The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1. By contrast, ablation of myogenin-expressing cells erased virtually all differentiated muscle cells, indicating that some aspects of the myogenic program are shared by most skeletal muscle cells. We conclude that Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo.
embryo, lung, germany, mice, expression, cell lineage, population, heart, research support, research, muscle, muscle cells, skeletal muscle, cell ablation, Myf5, myogenic cell lineages
1477-9129
1597-1604
Gensch, Nicole
34aad75f-db58-4cdb-b2e4-3e13d076fece
Borchardt, Thilo
6db67400-b4b0-45ea-9f54-3d124244e542
Schneider, Andre
5aa948fd-e06d-4c5f-b087-72eb2770d1d1
Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Braun, Thomas
cf3a2b8c-1824-40bc-a874-5dd4de9fbca4
Gensch, Nicole
34aad75f-db58-4cdb-b2e4-3e13d076fece
Borchardt, Thilo
6db67400-b4b0-45ea-9f54-3d124244e542
Schneider, Andre
5aa948fd-e06d-4c5f-b087-72eb2770d1d1
Riethmacher, Dieter
1a0a0c2e-e94d-4d0a-a890-90107a2545bc
Braun, Thomas
cf3a2b8c-1824-40bc-a874-5dd4de9fbca4

Gensch, Nicole, Borchardt, Thilo, Schneider, Andre, Riethmacher, Dieter and Braun, Thomas (2008) Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development, 135 (9), 1597-1604. (doi:10.1242/dev.019331).

Record type: Article

Abstract

The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1. By contrast, ablation of myogenin-expressing cells erased virtually all differentiated muscle cells, indicating that some aspects of the myogenic program are shared by most skeletal muscle cells. We conclude that Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo.

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More information

Published date: 26 March 2008
Keywords: embryo, lung, germany, mice, expression, cell lineage, population, heart, research support, research, muscle, muscle cells, skeletal muscle, cell ablation, Myf5, myogenic cell lineages

Identifiers

Local EPrints ID: 59743
URI: https://eprints.soton.ac.uk/id/eprint/59743
ISSN: 1477-9129
PURE UUID: ae76c154-0588-42f7-8493-2236d605e59d
ORCID for Dieter Riethmacher: ORCID iD orcid.org/0000-0002-4206-5529

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 03 Dec 2019 01:44

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