The University of Southampton
University of Southampton Institutional Repository

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis

Record type: Article

The development of myogenic cells is mainly determined by expression of two myogenic factors, Myf5 and Myod1 (MyoD), which genetically compensate for each other during embryogenesis. Here, we demonstrate by conditional cell ablation in mice that Myf5 determines a distinct myogenic cell population, which also contains some Myod1-positive cells. Ablation of this lineage uncovers the presence of a second autonomous myogenic lineage, which superseded Myf5-dependent myogenic cells and expressed Myod1. By contrast, ablation of myogenin-expressing cells erased virtually all differentiated muscle cells, indicating that some aspects of the myogenic program are shared by most skeletal muscle cells. We conclude that Myf5 and Myod1 define different cell lineages with distinct contributions to muscle precursor cells and differentiated myotubes. Individual myogenic cell lineages seem to substitute for each other within the developing embryo.

Full text not available from this repository.

Citation

Gensch, Nicole, Borchardt, Thilo, Schneider, Andre, Riethmacher, Dieter and Braun, Thomas (2008) Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis Development, 135, (9), pp. 1597-1604. (doi:10.1242/dev.019331).

More information

Published date: 26 March 2008
Keywords: embryo, lung, germany, mice, expression, cell lineage, population, heart, research support, research, muscle, muscle cells, skeletal muscle, cell ablation, Myf5, myogenic cell lineages

Identifiers

Local EPrints ID: 59743
URI: http://eprints.soton.ac.uk/id/eprint/59743
ISSN: 1477-9129
PURE UUID: ae76c154-0588-42f7-8493-2236d605e59d

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 17 Jul 2017 14:24

Export record

Altmetrics

Contributors

Author: Nicole Gensch
Author: Thilo Borchardt
Author: Andre Schneider
Author: Thomas Braun

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×