Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration
Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).
Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.
Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50).
Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.
537-540
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
Madhusudhana, K.C.
38366182-3e2e-43fe-9fdd-d437bf7907d7
Cree, A.J.
6724b71b-8828-4abb-971f-0856c2af555e
Luff, A.J.
91a9d311-a6c6-4cf8-8aa2-d4129c6a3cdb
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
April 2008
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
Madhusudhana, K.C.
38366182-3e2e-43fe-9fdd-d437bf7907d7
Cree, A.J.
6724b71b-8828-4abb-971f-0856c2af555e
Luff, A.J.
91a9d311-a6c6-4cf8-8aa2-d4129c6a3cdb
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Goverdhan, S.V., Ennis, S., Hannan, S.R., Madhusudhana, K.C., Cree, A.J., Luff, A.J. and Lotery, A.J.
(2008)
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
British Journal of Ophthalmology, 92 (4), .
(doi:10.1136/bjo.2007.123190).
(PMID:18310311)
Abstract
Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).
Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.
Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50).
Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.
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e-pub ahead of print date: 29 February 2008
Published date: April 2008
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 59778
URI: http://eprints.soton.ac.uk/id/eprint/59778
ISSN: 0007-1161
PURE UUID: 9c445635-ed08-4ae2-a4eb-257ba5b4cb8a
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Date deposited: 29 Oct 2008
Last modified: 16 Mar 2024 03:47
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Author:
S.V. Goverdhan
Author:
S.R. Hannan
Author:
K.C. Madhusudhana
Author:
A.J. Luff
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