The University of Southampton
University of Southampton Institutional Repository

Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration

Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration
Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration
Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).

Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.

Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50).

Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.
0007-1161
537-540
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
Madhusudhana, K.C.
38366182-3e2e-43fe-9fdd-d437bf7907d7
Cree, A.J.
6724b71b-8828-4abb-971f-0856c2af555e
Luff, A.J.
91a9d311-a6c6-4cf8-8aa2-d4129c6a3cdb
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Goverdhan, S.V.
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Ennis, S.
7b57f188-9d91-4beb-b217-09856146f1e9
Hannan, S.R.
59e67ba3-13ba-4ae6-a1d3-80b1f8c0292f
Madhusudhana, K.C.
38366182-3e2e-43fe-9fdd-d437bf7907d7
Cree, A.J.
6724b71b-8828-4abb-971f-0856c2af555e
Luff, A.J.
91a9d311-a6c6-4cf8-8aa2-d4129c6a3cdb
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Goverdhan, S.V., Ennis, S., Hannan, S.R., Madhusudhana, K.C., Cree, A.J., Luff, A.J. and Lotery, A.J. (2008) Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. British Journal of Ophthalmology, 92 (4), 537-540. (doi:10.1136/bjo.2007.123190). (PMID:18310311)

Record type: Article

Abstract

Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD).

Methods: DNA from 478 cases with AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T and anti-inflammatory IL10 -1082G/A cytokine polymorphisms using the 5' nuclease TaqMan(R) assay for allelic discrimination. Associations with AMD were analysed using allelic frequencies.

Results: The -251A allele of the IL8 promoter gene polymorphism was more prevalent in AMD patients than controls (p = 0.037, OR = 1.21, 95% CI = 1.01 to 1.44). Adjusting for age, sex, body mass index (BMI), current smoking and past smoking status did not alter the AMD association significantly (corrected p value = 0.043, OR = 1.23, 95% CI = 1.0 to 1.50).

Conclusion: The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine.

Full text not available from this repository.

More information

e-pub ahead of print date: 29 February 2008
Published date: April 2008
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 59778
URI: http://eprints.soton.ac.uk/id/eprint/59778
ISSN: 0007-1161
PURE UUID: 9c445635-ed08-4ae2-a4eb-257ba5b4cb8a
ORCID for S. Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for A.J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 29 Oct 2008
Last modified: 10 Dec 2019 01:50

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×