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The human fetal adrenal cortex and the window of sexual differentiation

The human fetal adrenal cortex and the window of sexual differentiation
The human fetal adrenal cortex and the window of sexual differentiation
Understanding normal development is fundamental to appreciating postnatal morphology, physiology and, in some instances, pathophysiology. Developmental biology tends to interrogate models in nonprimate species, for instance the mouse, where genetic manipulation gives privileged insight into the function of particular genes. Some human developmental processes, as occur in the adrenal gland, are not faithfully reproduced in these rodent models, yet have an impact on the pathophysiology and treatment of endocrine disorders, such as congenital adrenal hyperplasia. In this setting, in vitro research of normal human development complements clinical investigation of patients born with congenital disorders
adrenal cortex, congenital, biology, physiology, patients, stem cells, stem-cells, testis, treatment, male, etiology, in-vitro, review, research support, genes, research, regeneration, differentiation, in vitro, adrenal hyperplasia, biological, human, sex differentiation, models, androgens, humans, biosynthesis, fetal, embryology
1043-2760
391-397
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Arlt, Wiebke
fcf7aa71-468a-4097-b2cc-a04b283e53c7
Hanley, Neil A.
bf03f7bb-f377-44fb-8344-0bb1ca8b2ef9
Arlt, Wiebke
fcf7aa71-468a-4097-b2cc-a04b283e53c7

Hanley, Neil A. and Arlt, Wiebke (2006) The human fetal adrenal cortex and the window of sexual differentiation. Trends in Endocrinology & Metabolism, 17 (10), 391-397. (doi:10.1016/j.tem.2006.10.001).

Record type: Article

Abstract

Understanding normal development is fundamental to appreciating postnatal morphology, physiology and, in some instances, pathophysiology. Developmental biology tends to interrogate models in nonprimate species, for instance the mouse, where genetic manipulation gives privileged insight into the function of particular genes. Some human developmental processes, as occur in the adrenal gland, are not faithfully reproduced in these rodent models, yet have an impact on the pathophysiology and treatment of endocrine disorders, such as congenital adrenal hyperplasia. In this setting, in vitro research of normal human development complements clinical investigation of patients born with congenital disorders

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More information

Published date: December 2006
Keywords: adrenal cortex, congenital, biology, physiology, patients, stem cells, stem-cells, testis, treatment, male, etiology, in-vitro, review, research support, genes, research, regeneration, differentiation, in vitro, adrenal hyperplasia, biological, human, sex differentiation, models, androgens, humans, biosynthesis, fetal, embryology

Identifiers

Local EPrints ID: 59807
URI: http://eprints.soton.ac.uk/id/eprint/59807
ISSN: 1043-2760
PURE UUID: 43e7b797-0449-4475-8277-2306163523b0

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Date deposited: 04 Sep 2008
Last modified: 15 Mar 2024 11:17

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Contributors

Author: Neil A. Hanley
Author: Wiebke Arlt

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