Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells? (In special issue: Stem cells and progenitors in organ maintenance, regeneration and replacement: the role of hormones and growth factors in health and disease)

Hanley, Neil A., Hanley, Karen Piper, Miettinen, Päivi J. and Otonkoski, Timo (2008) Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells? (In special issue: Stem cells and progenitors in organ maintenance, regeneration and replacement: the role of hormones and growth factors in health and disease). Molecular and Cellular Endocrinology, 288 (1-2), 79-85. (doi:10.1016/j.mce.2008.03.001).

Abstract

Understanding how beta-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether beta-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans.

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