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The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1

The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1
The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1
We have investigated two patients with acquired chromosomal rearrangements, a male presenting with a t(1;9)(p34;q34) and B cell progenitor acute lymphoid leukemia and a female presenting with a t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome. We determined that the t(1;9) fused ABL to SFPQ (also known as PSF), a gene mapping to 1p34 that encodes a polypyrimidine tract-binding protein-associated splicing factor. The t(8;12) fused CPSF6, a cleavage and polyadenylation specificity factor, to FGFR1. The fusions were confirmed by amplification of the genomic breakpoints and RT-PCR. The predicted oncogenic products of these fusions, SFPQ-ABL and CPSF6-FGFR1, are in-frame and encode the N-terminal domain of the partner protein and the entire tyrosine kinase domain and C-terminal sequences of ABL and FGFR1. SFPQ interacts with two FGFR1 fusion partners, ZNF198 and CPSF6, that are functionally related to the recurrent PDGFRalpha partner FIP1L1. Our findings thus identify a group of proteins that are important for pre-mRNA processing as fusion partners for tyrosine kinases in hematological malignancies
laboratories, proteins, patients, protein, male, syndrome, tyrosine, research support, genetics, leukemia, female, human, research
1045-2257
379-385
Hidalgo-Curtis, Claire
5aaa8cfa-7271-48ee-8538-27736ab3eaf2
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Drachenberg, Milton
ee5a6ba4-51fa-4c6f-bf36-f9288c77b2e7
Roberts, Mark W.
805b7e3f-d376-441d-b3ca-414c7e6ce6eb
Finkelstein, Jerry Z.
64e194e3-f0d6-4765-b1ed-bc6e3d2242c4
Mould, Sarah
1beb42f6-2dc0-4e7e-8922-14d60b08e2d7
Oscier, David
2e7f0cc1-93e2-441e-857d-7314efae08ec
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31
Hidalgo-Curtis, Claire
5aaa8cfa-7271-48ee-8538-27736ab3eaf2
Chase, Andrew
a40a09c2-3073-4655-ba0b-a802e34914b5
Drachenberg, Milton
ee5a6ba4-51fa-4c6f-bf36-f9288c77b2e7
Roberts, Mark W.
805b7e3f-d376-441d-b3ca-414c7e6ce6eb
Finkelstein, Jerry Z.
64e194e3-f0d6-4765-b1ed-bc6e3d2242c4
Mould, Sarah
1beb42f6-2dc0-4e7e-8922-14d60b08e2d7
Oscier, David
2e7f0cc1-93e2-441e-857d-7314efae08ec
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Grand, Francis H.
89bd846f-638a-4bda-b8a9-8a1989021b31

Hidalgo-Curtis, Claire, Chase, Andrew, Drachenberg, Milton, Roberts, Mark W., Finkelstein, Jerry Z., Mould, Sarah, Oscier, David, Cross, Nicholas C.P. and Grand, Francis H. (2008) The t(1;9)(p34;q34) and t(8;12)(p11;q15) fuse pre-mRNA processing proteins SFPQ (PSF) and CPSF6 to ABL and FGFR1. Genes, Chromosomes and Cancer, 47 (5), 379-385. (doi:10.1002/gcc.20541).

Record type: Article

Abstract

We have investigated two patients with acquired chromosomal rearrangements, a male presenting with a t(1;9)(p34;q34) and B cell progenitor acute lymphoid leukemia and a female presenting with a t(8;12)(p11;q15) and the 8p11 myeloproliferative syndrome. We determined that the t(1;9) fused ABL to SFPQ (also known as PSF), a gene mapping to 1p34 that encodes a polypyrimidine tract-binding protein-associated splicing factor. The t(8;12) fused CPSF6, a cleavage and polyadenylation specificity factor, to FGFR1. The fusions were confirmed by amplification of the genomic breakpoints and RT-PCR. The predicted oncogenic products of these fusions, SFPQ-ABL and CPSF6-FGFR1, are in-frame and encode the N-terminal domain of the partner protein and the entire tyrosine kinase domain and C-terminal sequences of ABL and FGFR1. SFPQ interacts with two FGFR1 fusion partners, ZNF198 and CPSF6, that are functionally related to the recurrent PDGFRalpha partner FIP1L1. Our findings thus identify a group of proteins that are important for pre-mRNA processing as fusion partners for tyrosine kinases in hematological malignancies

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More information

Published date: 18 January 2008
Keywords: laboratories, proteins, patients, protein, male, syndrome, tyrosine, research support, genetics, leukemia, female, human, research

Identifiers

Local EPrints ID: 59823
URI: http://eprints.soton.ac.uk/id/eprint/59823
ISSN: 1045-2257
PURE UUID: 4e510a16-8fd9-44e6-a6a3-72e2c4e833a8
ORCID for Andrew Chase: ORCID iD orcid.org/0000-0001-6617-9953
ORCID for Nicholas C.P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 16 Mar 2024 03:23

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Contributors

Author: Claire Hidalgo-Curtis
Author: Andrew Chase ORCID iD
Author: Milton Drachenberg
Author: Mark W. Roberts
Author: Jerry Z. Finkelstein
Author: Sarah Mould
Author: David Oscier
Author: Francis H. Grand

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