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Interleukin-10 polymorphisms, cancer susceptibility and prognosis

Interleukin-10 polymorphisms, cancer susceptibility and prognosis
Interleukin-10 polymorphisms, cancer susceptibility and prognosis
Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions and may have both tumour-promoting and -inhibiting properties. A large number of polymorphisms (primarily single nucleotide polymorphisms (SNPs)) have been identified in the IL-10 gene promoter. Convincing evidence that certain of these polymorphisms are associated with differential expression of IL-10 in vitro and in some cases in vivo has been obtained and a number of studies have investigated associations between IL-10 polymorphisms and cancer susceptibility/prognosis. The results from 22 studies in 13 different malignancies are reviewed. In 17 of these studies, positive associations between IL-10 genotype or haplotype and disease susceptibility and/or progression were reported. In some of these cancers genotypes associated with low IL-10 expression were a risk factor for disease or disease progression, while in others genotypes associated with high IL-10 expression were a risk factor. Published findings in breast cancer are as yet conflicting. Most, but not all of the studies reviewed are based on small sample sizes and a limited number of IL-10 polymorphisms. However, the preliminary data obtained thus far indicate that larger studies are required in a number of cancers, in order to confirm initial results, extend studies to include more detailed genotype/haplotype analysis and combine genotype and gene expression studies in the same subjects. Such studies will contribute significantly to our understanding of the biological role of IL-10 in cancer development.
pathology, genetics, interleukin-10, in-vitro, role, polymorphism, expression, breast cancer, hospitals, disease, cancer, neoplasms, humans, genotype, genetic, gene expression
1389-9600
143-149
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Rose-Zerilli, M.J.
5b58c2f6-62b2-4683-a777-cae95cdf1c62
Howell, W.M.
dc6fe896-2230-4cf3-9862-f979cb872454
Rose-Zerilli, M.J.
5b58c2f6-62b2-4683-a777-cae95cdf1c62

Howell, W.M. and Rose-Zerilli, M.J. (2006) Interleukin-10 polymorphisms, cancer susceptibility and prognosis. Familial Cancer, 5 (2), 143-149. (doi:10.1007/s10689-005-0072-3).

Record type: Article

Abstract

Interleukin-10 (IL-10) is a multifunctional cytokine with both immunosuppressive and anti-angiogenic functions and may have both tumour-promoting and -inhibiting properties. A large number of polymorphisms (primarily single nucleotide polymorphisms (SNPs)) have been identified in the IL-10 gene promoter. Convincing evidence that certain of these polymorphisms are associated with differential expression of IL-10 in vitro and in some cases in vivo has been obtained and a number of studies have investigated associations between IL-10 polymorphisms and cancer susceptibility/prognosis. The results from 22 studies in 13 different malignancies are reviewed. In 17 of these studies, positive associations between IL-10 genotype or haplotype and disease susceptibility and/or progression were reported. In some of these cancers genotypes associated with low IL-10 expression were a risk factor for disease or disease progression, while in others genotypes associated with high IL-10 expression were a risk factor. Published findings in breast cancer are as yet conflicting. Most, but not all of the studies reviewed are based on small sample sizes and a limited number of IL-10 polymorphisms. However, the preliminary data obtained thus far indicate that larger studies are required in a number of cancers, in order to confirm initial results, extend studies to include more detailed genotype/haplotype analysis and combine genotype and gene expression studies in the same subjects. Such studies will contribute significantly to our understanding of the biological role of IL-10 in cancer development.

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More information

Published date: June 2006
Keywords: pathology, genetics, interleukin-10, in-vitro, role, polymorphism, expression, breast cancer, hospitals, disease, cancer, neoplasms, humans, genotype, genetic, gene expression

Identifiers

Local EPrints ID: 59862
URI: http://eprints.soton.ac.uk/id/eprint/59862
ISSN: 1389-9600
PURE UUID: 085f5d7a-fcf7-4e36-ad95-a7f524c1734c

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Date deposited: 05 Sep 2008
Last modified: 13 Mar 2019 20:30

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Contributors

Author: W.M. Howell
Author: M.J. Rose-Zerilli

University divisions

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