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The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study

The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study
The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study
It has been hypothesised that paraoxonase genes would be related to adverse pregnancy outcomes, via a maternal or fetal effect on placental hypoperfusion and thrombosis. To date only two studies have assessed this possibility. In this study we assessed the associations of the PON1 Q192R polymorphism with self-report of having pregnancy-induced hypertension, gestational hyperglycaemia and a preterm offspring birth. The associations were assessed in 3266 white women who were randomly selected from 23 British towns. There was no association between PON1 Q192R and either self-report of pregnancy-induced hypertension or gestational hyperglycaemia but the prevalence of reporting having a preterm birth increased with each R allele: per allele odds ratio 1.20 [95% confidence interval (CI) 1.03, 1.41]. When our results were pooled with the one previous study of the association of this polymorphism with preterm birth, the pooled per allele odds ratio was 1.19 [95% CI 1.02, 1.39]. Our findings provide some further evidence to suggest that PON1 Q192R is associated with preterm birth; they invite further investigation of both maternal and fetal genotype for PON1 Q192R in relation to preterm birth.
pregnancy complications, pregnancy outcome, heart, physiology, genetics, infant, cohort, fetal, health, pregnancy, polymorphism, epidemiology, hypertension, complications
0269-5022
244-250
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
Hinks, Lesley J.
26543550-2e57-4947-9737-25c4c4ab1163
Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Timpson, Nick
91f6a11f-f375-43d7-87f9-ede6f090f161
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Ebrahim, Shah
0f2ade5c-4ef6-4ca7-9f9b-9b60ba192b13
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Gaunt, Tom R.
ff4bc39d-405c-4ba1-896b-7e7d2f747387
Hinks, Lesley J.
26543550-2e57-4947-9737-25c4c4ab1163
Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Timpson, Nick
91f6a11f-f375-43d7-87f9-ede6f090f161
Day, Ian N.M.
b749b30a-1f4c-40eb-af0e-a50427388b39
Ebrahim, Shah
0f2ade5c-4ef6-4ca7-9f9b-9b60ba192b13

Lawlor, Debbie A., Gaunt, Tom R., Hinks, Lesley J., Smith, George Davey, Timpson, Nick, Day, Ian N.M. and Ebrahim, Shah (2006) The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. Paediatric and Perinatal Epidemiology, 20 (3), 244-250. (doi:10.1111/j.1365-3016.2006.00716.x).

Record type: Article

Abstract

It has been hypothesised that paraoxonase genes would be related to adverse pregnancy outcomes, via a maternal or fetal effect on placental hypoperfusion and thrombosis. To date only two studies have assessed this possibility. In this study we assessed the associations of the PON1 Q192R polymorphism with self-report of having pregnancy-induced hypertension, gestational hyperglycaemia and a preterm offspring birth. The associations were assessed in 3266 white women who were randomly selected from 23 British towns. There was no association between PON1 Q192R and either self-report of pregnancy-induced hypertension or gestational hyperglycaemia but the prevalence of reporting having a preterm birth increased with each R allele: per allele odds ratio 1.20 [95% confidence interval (CI) 1.03, 1.41]. When our results were pooled with the one previous study of the association of this polymorphism with preterm birth, the pooled per allele odds ratio was 1.19 [95% CI 1.02, 1.39]. Our findings provide some further evidence to suggest that PON1 Q192R is associated with preterm birth; they invite further investigation of both maternal and fetal genotype for PON1 Q192R in relation to preterm birth.

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More information

Published date: 7 April 2006
Keywords: pregnancy complications, pregnancy outcome, heart, physiology, genetics, infant, cohort, fetal, health, pregnancy, polymorphism, epidemiology, hypertension, complications

Identifiers

Local EPrints ID: 59970
URI: http://eprints.soton.ac.uk/id/eprint/59970
ISSN: 0269-5022
PURE UUID: 99d2c7ed-9d57-4fd6-8e1e-2e3662a654ce

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Date deposited: 05 Sep 2008
Last modified: 15 Mar 2024 11:18

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Contributors

Author: Debbie A. Lawlor
Author: Tom R. Gaunt
Author: Lesley J. Hinks
Author: George Davey Smith
Author: Nick Timpson
Author: Ian N.M. Day
Author: Shah Ebrahim

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