Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy

The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases. Recent molecular genetic analysis has provided a scientific basis for this observation. Underlying myeloproliferative disorders are acquired abnormalities of tyrosine kinase genes. These may be chromosomal translocations resulting in the creation of a fusion kinase gene, examples of which include ABL, FGFR, and PDGFR as seen in disorders CML, 8p11 myeloproliferative syndrome, atypical CML and chronic eosinophilic leukaemia. The second group of tyrosine kinase abnormalities are point mutations in JAK2, a cytosolic TK. This abnormality is seen in 30-97% of cases of MPD with the phenotype PV, ET or CIMF

myelofibrosis, observation, myeloproliferative disorders, receptor, gene expression regulation, humans, hematopoiesis, thrombocythemia, mutant chimeric proteins, proteins, genetics, disease, enzymology, chronic disease, therapy, protein-tyrosine kinase, fibroblast growth factor, growth, neoplastic, myelogenous, platelet-derived growth factor, pathology, diagnosis, oncogene proteins, mutation, hypereosinophilic syndrome, platelet-derived growth factor alpha, analysis, phenotype, chronic, molecular diagnostic techniques, janus kinase 2, review, role, tyrosine, fusion, polycythemia vera, genes, alpha, human, classification, mrna cleavage and polyadenylation factors, leukemia, london, enzymologic, blood, bcr-abl positive, abnormalities, protein, platelet-derived growth factor beta, protein-tyrosine kinases, point mutation, hemorrhagic, syndrome, type 1

10.1159/000101707

81-88

Macdonald, Donald

994e78d2-0c82-46fe-b90c-10b81b8e4995

Cross, Nicholas C.

f87650da-b908-4a34-b31b-d62c5f186fe4

June 2007

Macdonald, Donald

994e78d2-0c82-46fe-b90c-10b81b8e4995

Cross, Nicholas C.

f87650da-b908-4a34-b31b-d62c5f186fe4

Macdonald, Donald and Cross, Nicholas C. (2007) Chronic myeloproliferative disorders: the role of tyrosine kinases in pathogenesis, diagnosis and therapy. Pathobiology, 74 (2), 81-88. (doi:10.1159/000101707).

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Published date: June 2007

Keywords: myelofibrosis, observation, myeloproliferative disorders, receptor, gene expression regulation, humans, hematopoiesis, thrombocythemia, mutant chimeric proteins, proteins, genetics, disease, enzymology, chronic disease, therapy, protein-tyrosine kinase, fibroblast growth factor, growth, neoplastic, myelogenous, platelet-derived growth factor, pathology, diagnosis, oncogene proteins, mutation, hypereosinophilic syndrome, platelet-derived growth factor alpha, analysis, phenotype, chronic, molecular diagnostic techniques, janus kinase 2, review, role, tyrosine, fusion, polycythemia vera, genes, alpha, human, classification, mrna cleavage and polyadenylation factors, leukemia, london, enzymologic, blood, bcr-abl positive, abnormalities, protein, platelet-derived growth factor beta, protein-tyrosine kinases, point mutation, hemorrhagic, syndrome, type 1

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